海南医学院学报2017，Vol.23Issue(8)：1092-1094,1098,4.DOI:10.13210/j.cnki.jhmu.20170406.054
痤疮患者病灶及外周血中TLRs家族的表达量及其对炎症介质合成的调节作用
The TLRs family expression in lesions and peripheral blood of patients with acne and their regulating effect on the synthesis of inflammatory mediators
摘要
Abstract
Objective: To study the TLRfamily expression in lesionand peripheral blood of patientwith acne and theiregulating effecon the synthesiof inflammatorymediators.Methods:60 patientwith acne vulgariwho were treated in ouhospital between June 2013 and July 2016 were selected athe acne group,and 48 patientwith traumwho accepted debridemenand suturing in ohspital during the same period were selected athe control group.The acne focutissue and the skin tissue aftedebridemenwere collected to determine the expression of TLRand in flammatory mediators,and the peripheral blood mononucleacellwere collected to determine the expression of TLRs.Results:TLR2and TLR4 protein expression in skinissue and peripheral blood mononucleacellof acne group were significantly highethan those of control group while the TLR3,TLR5,TLR7and TLR9 protein expression were nosignificantly differenfrom those of control group;IL-1α,IL-1β,IL-8andTNF-αlevelin acne tissue with high TLR2and TLR4 expression were significantly highethan those in acne tissue with low TLR2 and TLR4 expression.Conclusion:TLR2 and TLR4 are highly expressed in lesionand peripheral blood of patientswith acne and havepromoting effecon the synthesiof inflammatory mediators.关键词
痤疮/丙酸杆菌/Toll样受体(tolllikereceptors,TLRs)/炎症介质Key words
Acne/Propionibacterium/Toll-like receptor/Inflammatory mediator分类
医药卫生引用本文复制引用
薛强东,李青,周荣华,张雅洁,王启操,邱佳玲..痤疮患者病灶及外周血中TLRs家族的表达量及其对炎症介质合成的调节作用[J].海南医学院学报,2017,23(8):1092-1094,1098,4.基金项目
广东省医学科学技术研究基金项目(WSTJJ20101210511122197907049029) （WSTJJ20101210511122197907049029）
It is supported by the Science and Technology Foundation Project of Shaanxi Province (2013-SF2-14). （2013-SF2-14）
