海南医学院学报2017，Vol.23Issue(8)：1157-1160,4.DOI:10.13210/j.cnki.jhmu.20170525.010
高强度聚焦超声联合介入栓塞化疗对晚期宫颈癌病灶生长及细胞侵袭的影响
Effects of high-intensity focused ultrasound combined with interventional chemoembolization on the advanced cervical cancer lesion growth and cell invasion
摘要
Abstract
Objective: To study the effectof high-intensity focused ultrasound (HIFU) combined with interventional chemoembolization on the advanced cervical cancelesion growth and cell invasion.Methods: Patientwith stage IIB-IVcervical cancetreated in Suining Hospital of TCM between May 2014 and Octobe2016 were selected and randomly divided into two groups, HIFU group received HIFU combined with interventional chemoembolization, and the control group accepted interventional chemoembolization.The levelof tumomarkerin serum awell athe expression of tumosuppressogeneand invasion genein tumolesionwere determined before and aftetreatment.Results: 2 weeks, 3 weekand 4 weekaftetreatment, serum TK-1, SCand CA125 levelof both groupwere lowethan those before treatment, serum TK-1, SCand CA125 levelof HIFU group 2 weekaftetreatmenwere nodifferenfrom those of control group, and serum TK-1, SCand CA125 levelof HIFU group 3 weekand 4 weekaftetreatmenwere significantly lowethan those of control group;4 weekaftetreatment, AIF, NDRG4, SARI and eIF4E3 mRNexpression in tumolesionof both groupwere highethan those before treatmenwhile FAK, KGFand MMP9 mRNexpression were lowethan those before treatment, and AIF, NDRG4, SARI and eIF4E3 mRNexpression in tumolesionof HIFU group were highethan those of control group while FAK, KGFand MMP9 mRNexpression were lowethan those of control group.Conclusion: HIFU combined with interventional chemoembolization can be more effective in suppressing the advanced cervical cancelesion growth and cell invasion than interventional chemoembolization alone.关键词
宫颈癌/高强度聚焦超声/介入栓塞化疗/抑癌基因/侵袭Key words
Cervical cancer/High-intensity focused ultrasound/Interventional chemoembolization/Tumor suppressor gene/Invasion分类
医药卫生引用本文复制引用
王华,郭旭..高强度聚焦超声联合介入栓塞化疗对晚期宫颈癌病灶生长及细胞侵袭的影响[J].海南医学院学报,2017,23(8):1157-1160,4.基金项目
四川省中医药管理资助课题[2013A09-4] （）
project supported by Sichuan provincial management of traditional Chinese medicine [2013A09-4] （）
