扬州大学学报（农业与生命科学版）2017，Vol.38Issue(1)：20-25,6.DOI:10.16872/j.cnki.1671-4652.2017.01.005
耐热新城疫弱毒株及其热稳定机制研究进展
The research progress in heat-resistant Newcastle disease virus attenuated strain and mechanism of thermostability
摘要
Abstract
Newcastle disease (ND) is a highly contagious avian disease,which can cause severe economic losses in the poultry industry.Vaccination is the major means of preventing and controlling ND.The selection and development of heat-resistant Newcastle disease virus (NDV) attenuated strains are of critical economic significance.In this paper,the research development of heat-resistant NDV attenuated strains at home and abroad was reviewed;the biological characteristics,immunogenicity and applications of heat-resistant NDV attenuated strains and candidate vaccine strains were summarized;the mechanism underlying the thermostability of heat-resistant NDV strains was reviewed.Combing with modern protein molecular dynamics simulation and reverse genetic technology,the authors also presented an outlook of molecular mechanism analysis of NDV thermostability and the development of new-type heat-resistant vaccine strains.关键词
新城疫病毒/热稳定弱毒株/热稳定机制Key words
Newcastle disease virus/heat-resistant attenuated strain/mechanism of thermostability分类
农业科技引用本文复制引用
曹永忠,张小荣,黄国胜,刘倩,吴艳涛,刘秀梵..耐热新城疫弱毒株及其热稳定机制研究进展[J].扬州大学学报（农业与生命科学版）,2017,38(1):20-25,6.基金项目
国家重点研发计划项目(2016YFD0501604) （2016YFD0501604）
江苏省自然科学基金资助项目(BK20141274) （BK20141274）
扬州大学创新培育基金资助项目(2013CXJ063). （2013CXJ063）
