临床神经外科杂志2017，Vol.14Issue(3)：186-189,4.DOI:10.3969/j.issn.1672-7770.2017.03.007
室管膜下巨细胞星形细胞瘤的临床及病理特点分析(附2例报告)
Clinicopathological study on 2 cases of subependymal giant cell astrocytomas
摘要
Abstract
Objective To study the clinicopathology,immunohistochemical characteristic and the differential diagnosis of subependymal giant cell astrocytomas (SEGAs).Methods Two cases of SEGAs were studied by clinicopathological study and immunohistochemistry.Results Two cases of SEGAs occurred during the first two decades of life,arising in the wall of the lateral ventricles and were composed of gemistocytes and sweeping bundles of spindle cells with calcification.Immunohistochemistry showed GFAP,S-100,vimentin,Map-2,Nestin,SOX-2,Caspase-3,Caspase-9 and Bax positive;Neun,CD133,CD34 and Ki-67 negative.Conclusions SEGAs occur commonly in tuberous sclerosis complex,may arise from multipotent neural stem cells,have activation of apoptotic mechanisms and should be differentiated with gemistocytic diffuse astrocytoma,ependymoma,choroid plexus papilloma and subependymoma.关键词
室管膜下巨细胞星形细胞瘤/结节性硬化/免疫组化Key words
tuberous sclerosis complex/subependymal giant cell astrocytoma/immunohi stochemistry分类
医药卫生引用本文复制引用
梁乐,马康平,付静,李云林,姚晓香..室管膜下巨细胞星形细胞瘤的临床及病理特点分析(附2例报告)[J].临床神经外科杂志,2017,14(3):186-189,4.基金项目
北京市海淀医院/北京大学第三医院海淀院区青年科研项目(KYQ2017004) （KYQ2017004）
首都儿科研究所基金(Fx201704) （Fx201704）
