内科理论与实践2017，Vol.12Issue(2)：123-128,6.DOI:10.16138/j.1673-6087.2017.02.012
无创通气结合有氧运动治疗阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病
Efficacy of nasal continuous airway positive pressure ventilation combined with aerobic exercise rehabilitation in patients of obstructive sleep apnea hypopnea syndrome associated with type 2 diabetes mellitus
摘要
Abstract
Objective To evaluate the efficacy of nasal continuous airway positive pressure ventilation (nCPAP) and (or) aerobic exercise rehabilitation on sleep,body mnass index (BMI),blood glucose,blood lipids,blood pressure and coefficient of variation(CV) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) associated with (or without) type 2 diabetes mellitus (T2DM).Methods Ninety-six patients with T2DM were categorized into T2DM and T2DM associated with OSAHS groups.Sixty-six T2DM patients associated with OSAHS were divided into 2 groups:20 patients assigned to combined treatment group were given nCPAP and aerobic exercise rehabilitation for 20 weeks,while 46 patients assigned to treatment group were given aerobic exercise rehabilitation only.Results Compared with group of T2DM,no significant differences in age,gender,total cholesterol,triglycerides,low density lipoprotein cholesterol (LDL-C),and 24 h average diastolic blood pressure were found in T2DM associated with OSAHS group (all P＞0.05),and significant differences were found in blood glucose,glycosylated hemoglobin,insulin,homeostasis model assessment for insulin resistance （HOMA-IR),high density lipoprotein cholesterol(HDL-C),24 h average systolic blood pressure and CV (P＜0.01).After 20 weeks of treatment in patients with T2DM associated with OSAHS,the efficacy of nCPAP combined with aerobic exercise rehabilitation was significantly higher than aerobic exercise rehabilitation only in improvement of apnea hypopnea index (AHI),blood-glucose,glycosylated hemoglobin,insulin,HOMA-IR,HDL-C,CV of blood pressure(P＜0.05).BML fasting serum insulin(FINS),LDL-C,total cholesterol,triglycerides,24 h average systolic and diastolic blood pressure showed no significant differences between the two groups.Conclusions T2DM is closely related with OSAHS.nCPAP combined with low to moderate aerobic exercise rehabilitation is effective for improving sleep,BMI,blood glucose,blood lipids,blood inulin,CV of blood pressure in patients of T2DM associated with OSAHS.关键词
2型糖尿病/阻塞性睡眠呼吸暂停低通气综合征/经鼻持续呼吸道正压通气/康复Key words
Type 2 diabetes mellitus/Obstructive sleep apnea hypopnea syndrome/Nasal continuous airway positive pressure ventilation/Rehabilitation分类
医药卫生引用本文复制引用
任蕾,王年,杜井波,沈宏华,陈锐..无创通气结合有氧运动治疗阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病[J].内科理论与实践,2017,12(2):123-128,6.基金项目
上海市卫生和计划生育委员会科研课题(项目编号:201540060) （项目编号:201540060）
静安区卫生和计划生育委员会第三批十百千卫生人才培养计划(项目编号:JWRC2014D10) （项目编号:JWRC2014D10）
