内科理论与实践2017，Vol.12Issue(2)：129-134,6.DOI:10.16138/j.1673-6087.2017.02.013
糖基化终末产物受体基因单核苷酸多态性与动脉僵硬度及波反射的关系
Arterial stiffness and wave reflection in relation to genetic polymorphisms in receptor of advanced glycation end products
摘要
Abstract
Objective To investigate the arterial stiffness and wave reflection in relation to the Gly82Ser (rs2070600) and-374T/A (rs1800624) polymorphisms in receptor of advanced glycation end products (RAGE) in a Chinese population.Methods The study participants were recruited from a residential area in the suburb of Shanghai.Genotyping was performed using the SnapShot method.Plasma advanced glycation end products (AGEs) concentration was measured by the enzyme linked immunosorbent assay (ELISA) and logarithmically transformed for statistical analysis.Carotid-femoral pulse wave velocity (PWV) and peripheral and central augmentation indexes were determined using the Sphygmo Cor system as measures of arterial stiffness and wave reflection,respectively.Results The 968 subjects had a mean age of (55.2±13.0) years,and included 607 (62.7％) women,361 (37.3％) hypertensive patients,and 85 (8.8％) diabetic or prediabetic patients.The genotype frequencies of Gly82Ser(GlyGly 56.3％,GlySer 38.6％,and SerSer 5.1％) and-374T/A (TT 65.4％,TA 31.4％,and AA 3.2％) polymorphisms were in accordance with the Hardy-Weinberg equilibrium(allP＞0.05).Plasma AGEs concentration did not differ across the Gly82Ser or-374T/A genotypes(all P＞0.05).However,after adjustment for confounders,the difference in plasma AGEs concentration between-374A allele carriers and-374TT homozygotes reached statistical significance (5.5 mg/L vs.4.9 mg/L,P=0.02).None of the genetic associations with carotid-femoral PWV or central and peripheral augmentation indexes reached statistical significance (all P＞0.05),except for a borderline significant association between peripheral augmentation index and the Gly82Ser polymorphism (β3=0.14,P=0.049).Conclusions The genetic polymorphisms in RAGE were weakly associated with plasma AGEs concentration and peripheral augmentation index.关键词
糖基化终末产物受体/糖基化终末产物受体基因/Gly82Ser/-374T/A/动脉僵硬度/反射波增强指数Key words
Receptor of advanced glycation end products/Receptor of advanced glycation end products gene/Gly82Ser,-374T/A/Arterial stiffness/Wave reflections分类
医药卫生引用本文复制引用
刘常远,黄绮芳,李燕,王继光..糖基化终末产物受体基因单核苷酸多态性与动脉僵硬度及波反射的关系[J].内科理论与实践,2017,12(2):129-134,6.基金项目
国家自然科学基金项目(项目编号:81400312) （项目编号:81400312）
上海市科学技术委员会科研计划项目(项目编号:14ZR1436200) （项目编号:14ZR1436200）
