农药学学报2017，Vol.19Issue(3)：290-297,8.DOI:10.16801/j.issn.1008-7303.2017.0038
吩嗪-1-羧酸双酰肼衍生物的合成、杀菌活性及韧皮部的输导性研究
Synthesis, fungicidal activity and phloem mobility of phenazine-1-carboxylic acid diacylhydrazine derivatives
摘要
Abstract
Phenazine-1-carboxylic acid (PCA, Shenqinbactin) and its derivative phenazine-1-carboxylic hydrazine are natural products that have been characterized to have unique chemical structures and interesting bioactivities. However, neither of them has phloem mobility. In this paper, phenazine-1-carboxylic acid and maleic hydazide were used as the corporate lead compounds which were introduced into the diacylhydrazine scaffold, and17 new compounds were designed and synthesized. Their structures were confirmed by1H NMR, HRMS and X-Ray. The preliminary bioassay results showed that most of the compounds exhibited significant fungicidal activities againstThanatephorus cucumeris at the concentration of 50 mg/L. In particular, compound6m showed the best fungicidal activity against T. cucumeris with the rate of 92% at 50 mg/L. However, all target compounds do not have phloem mobility.关键词
吩嗪-1-羧酸(申嗪霉素)/马来酰肼/双酰肼/合成/杀菌活性/韧皮部输导性Key words
phenazine-1-carboxylic acid (shenqinbactin)/maleic hydazide/diacylhydrazine/synthesis/fungicidal activity/phloem mobility分类
化学化工引用本文复制引用
柳豪,余林花,熊志鹏,张敏,李俊凯,徐志红,吴清来..吩嗪-1-羧酸双酰肼衍生物的合成、杀菌活性及韧皮部的输导性研究[J].农药学学报,2017,19(3):290-297,8.基金项目
国家自然科学基金(30971948) （30971948）
湖北省自然科学基金(2014CF105). （2014CF105）
