生物技术通报2017，Vol.33Issue(6)：39-44,6.DOI:10.13560/j.cnki.biotech.bull.1985.2017-1168
基因编辑技术最新研究进展
Research Progresses in Gene Editing Techniques
摘要
Abstract
Gene editing is a powerful set of techniques for site-directed modification and knockout or insertion of the genes on genome or its transcripts. Recently,gene editing techniques have been greatly developed,which not only significantly promotes the process of gene function investigation,but also shows the potential applications for human genetic disease treatments. Here,we summarized the principles, advantages,disadvantages,and applications of gene editing methods including CRISPR/Cas9,CRISPR/Cpf1,Ago/gDNA and SGN in order to provide necessary informations on gene editing for the relevant scientific research.关键词
基因编辑/CRISPR/Cas9/CRISPR/Cpf1/Ago/gDNA/Structure-guided NucleaseKey words
Gene editing/CRISPR/Cas9/CRISPR/Cpf1/Ago/gDNA/Structure-guided Nuclease引用本文复制引用
刘玉彪,许馨,曹山虎,孙绍光..基因编辑技术最新研究进展[J].生物技术通报,2017,33(6):39-44,6.基金项目
国家自然科学基金项目(81670273,81200215),河北省高等学校科学技术研究优秀青年基金项目(YQ2013023),河北省高层次人才资助项目(A2016002073),河北医科大学大学生创新性实验计划项目(USIP2016026) （81670273,81200215）
