实用妇产科杂志2017，Vol.33Issue(5)：349-352,4.
垂体降调节对不明原因反复种植失败患者冻融胚胎移植周期的影响
The Effect of Long-Term Pituitary Down-Regulation before Frozen Embryo Transfer for Patients Suffering From Idiopathic Repeated Implantation Failure
摘要
Abstract
Objective:To explore the effect of long-term pituitary down-regulation before frozen-embryo transfer(FET) for idiopathic RIF patients.Methods:291 FET cycles of 118 idiopathic RIF patients who had undergone down-regulation protocol before FET was analyzed.There were 131 down-regulation cycles (Group A,118 cases)and 160 control cycles (Group B,95 cases).Demographic data,cycle characteristics and clinical outcome were compared.Results:Although patients in Group A had more previous attempts than Group B(2.40 ±0.10 vs 1.76 ±0.07,P ＜0.01),they have no significant differences in age,infertility duration,BMI,basal FSH,AFC,numbers of embryo transferred,embryo grade,and endometrium thickness(P ＞ 0.05).Compared with Group B,Group A achieved significantly higher biochemical pregnancy rate,clinical pregnancy rate,implantation rate,ongoing pregnancy rate (P ＜ 0.01) and significantly lower miscarriage rate (P ＜ 0.01).Conclusions:Long-term pituitary down-regulation protocol may help promoting clinical outcome of idiopathic RIF patients undergo FET.关键词
不明原因反复种植失败/冻融胚胎移植/垂体降调节Key words
Idiopathic repeated implantation failure/Frozen embryo transfer/Long-term pituitary down-regulation分类
医药卫生引用本文复制引用
蔡美虹,黄睿,梁晓燕,杨星..垂体降调节对不明原因反复种植失败患者冻融胚胎移植周期的影响[J].实用妇产科杂志,2017,33(5):349-352,4.基金项目
国家自然科学基金(编号:81470063) （编号:81470063）
广东省自然科学基金(编号:2014A030313129) （编号:2014A030313129）
广东省医学科学技术研究基金(编号:A2015025) （编号:A2015025）
