实用妇产科杂志2017，Vol.33Issue(5)：366-369,4.
宫腔镜联合孕激素治疗年轻患者早期子宫内膜癌的疗效及预后分析
Outcomes and Prognosis of Early Endometrial Carcinoma in Young Patients with Hysteroscopy Combined Progesterone Therapy
邓泽文 1赵祎琪 1曾玺 1叶麾 1郄明蓉1
作者信息
- 1. 四川大学华西第二医院 出生缺陷与相关妇儿疾病教育部重点实验室,四川 成都 610041
- 折叠
摘要
Abstract
Objective:To explore the therapeutic effect and prognosis of young patients(＜40 years old) with early endometrial carcinoma by hysteroscopy combined progesterone therapy.Methods:A retrospective analysis of the clinical pathological and follow-up data was conducted,including 16 young patients with early endometrial carcinoma voluntarily treated by hysteroscopy combined progestogen in West China Second University Hospital from January 2008 to December 2014.All patients were treated by uterine curettage under hysteroscopy or lesion resection and uterine curettage under hysteroscopy,7 patients took medroxyprogesterone acetate(MPA) 250 mg/d and the rest took megestrol acetate(MA) 160mg/d.After treatment and under follow-up,remission rates,recurrence rates and fertility circumstance of all patients were compared.Results:Median follow-up time was 54 months(17-90 months).The therapeutic effect resulted in 12 patients(75.0％) with complete remission,3 patients(18.8％) with partial remission,1 patient (6.2％) with non-reaction,and 3 patients (18.8％) with recurrence.The complete remission rate of medroxyprogesterone acetate and megestrol acetate group was 71.4％ (5/7) and 77.8％ (7/9),respectively,with no statistical difference(P ＞ 0.05).3 patients recurred after complete remission(1 in MPA,2 in MA),the average recurrence time was 42 months.8 patients(50.0％) had pregnancy (1 with gemellary pregnancy),6 of 9 (66.6％) delivered and 3 of 9 (33.3％) had abortion.Conclusions:Hysteroscopy combined progestogen therapy for young patients with early endometrial carcinoma is effective,and the therapeutic effect of MPA and MA has no significant difference.However,all patients should be treated with strict selection and follow-up due to the certain risk of recurrence.关键词
子宫内膜癌/宫腔镜联合孕激素/治疗效果/预后Key words
Endometrial carcinoma/Hysteroscopy combined progestogen therapy/Therapeutic effect/Prognosis分类
医药卫生引用本文复制引用
邓泽文,赵祎琪,曾玺,叶麾,郄明蓉..宫腔镜联合孕激素治疗年轻患者早期子宫内膜癌的疗效及预后分析[J].实用妇产科杂志,2017,33(5):366-369,4.
