生殖医学杂志2017，Vol.26Issue(6)：520-524,5.DOI:10.3969/j.issn.1004-3845.2017.06.004
微刺激全胚胎冷冻方案在常规IVF-ET治疗失败无优质胚胎患者中的应用
Application of mild stimulation protocol in the normal responders after failure of routine IVF-ET without high quality embryos
摘要
Abstract
Objective: To explore the clinical value of mild stimulation protocol applied in the normal responders after failure of routine IVF-ET without high quality embryos. Methods: A total of 106 normal responders were initially taken 124 cycles with conventional protocols. After unsuccessful pregnancy due to no high quality embryos,another 156 mild stimulation protocols were applied. A retrospective study was performed to compare the various parameters and clinical outcomes between the two protocols. Results: The days of gonadotropin (Gn) used [(7.24±2.41) vs. (10.59±1.81) days],the total doses of Gn used [(656.97±347.17) vs. (2 409.54±726.01) U],E2 levels on HCG day [(451.46±350.85) vs. (1 275.93±674.46) pmol/L],and the number of mature oocytes [(2.53±2.15) vs. (8.98±5.29)] were significantly lower in mild stimulation protocol than those of the conventional protocol (P<0.05),but the embryonic formation rate per oocyte (39.13%) in the mild stimulation protocol was significantly higher than that in the conventional protocol (12.81%) (P<0.05). There was no clinical pregnancy in the conventional group. Twenty-two clinical pregnancies were obtained in the 70 transfer cycles in the mild stimulation protocol. The clinical pregnancy rate was 31.43% (22/70),and the cumulative ongoing pregnancy rate was 18.87% (20/106). The embryo implantation rate and pregnancy rate in different age groups were significantly decreased along with age increased (P<0.05). Conclusions: Mild stimulation protocol used in the normal responders after failure of routine IVF-ET without high quality embryos can obtain good clinical outcomes.关键词
微刺激方案/全胚冷冻/优质胚胎/体外受精-胚胎移植Key words
Mild sitmulation protocol/Frozen embryos/High quality embryos/IVF-ET引用本文复制引用
孔娜,刘景瑜,孙海翔..微刺激全胚胎冷冻方案在常规IVF-ET治疗失败无优质胚胎患者中的应用[J].生殖医学杂志,2017,26(6):520-524,5.基金项目
国家自然科学基金青年科学基金项目(81601246) （81601246）
