生殖医学杂志2017，Vol.26Issue(6)：525-530,6.DOI:10.3969/j.issn.1004-3845.2017.06.005
性发育异常性腺肿瘤患者术后生存质量评估研究
Investigation of quality of life in patients after operation of sex development disorder with gonadal tumor
摘要
Abstract
Objective: To investigate the quality of life (QOL) in patients after operation with of sex development disorders with gonadal tumors,and propose some suggestions of long-term care. Methods: Twenty four patients after operation of disorders of sex development with gonadal tumors diagnosed in Peking Union Medical College Hospital from January 2006 to December 2015 were enrolled in the study. All patients were followed-up and provided psychological support after surgery. WHOQOL-BREF questionnaires including physical,psychological,and social relationship and environmental domains were used for QOL evaluation. Results: The age of initial treatment in DSD patients with gonadal tumors was (19.25±4.75) years old (ranging from 13 to 29 years). All individuals are phenotypic female and were closely followed-up for (4.79±2.36) years (ranging from 1 to 10 years). There were 15 (62.50%) 46,XY pure gonadal dysgenesis (46,XY PGD),6 (25.00%) androgen insensitivity syndrome (AIS),3 (12.50%) XO/XY gonadal dysgenesis (Mixed GD) patients involved. QOL scores of psychological domain in different DSD categories were lower than that of other domains,and Mixed GD patients carried the lowest psychological QOL score. DSD patients with tumors had better QOL scores than general DSD patients and the general urban adult population (P<0.05). There was no significantly difference between the QOL scores of DSD patients with benign (n=11) and malignant tumors (n=13) (P>0.05). Conclusions: With optimal care,including close follow-ups and psychological support,DSD patients with gonadal tumors are expected to achieve ideal QOL.关键词
性发育异常/性腺肿瘤/生殖细胞肿瘤/生存质量/心理支持Key words
Sex development disorder/Gonadal tumors/Germ cell tumors/Quality of life/Psychological support引用本文复制引用
黄禾,TiffanyTian,田秦杰..性发育异常性腺肿瘤患者术后生存质量评估研究[J].生殖医学杂志,2017,26(6):525-530,6.基金项目
国家自然科学基金面上项目(81671424) （81671424）
