生殖医学杂志2017，Vol.26Issue(6)：537-545,9.DOI:10.3969/j.issn.1004-3845.2017.06.007
宫腔内灌注G-CSF对改善薄型子宫内膜临床疗效的系统评价与Meta分析
Effectiveness of intrauterine infusion of granulocyte colony-stimulating factor for thin endometrium: a systematic review and meta-analysis
摘要
Abstract
Objective: To systematically review the effectiveness of transvaginal intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for the patients with thin endometrium and providing evidence for clinical treatment. Methods: Several different electronic databases including PubMed,Embase,CNKI and so forth were searched from inception to July 1st 2016. Study selection,data extraction,bias evaluation and quality assessment were performed by two reviewers independently. Then,meta-analysis was performed using Revman 5.3 software. Results: Fourteen eligible studies involving 944 patients varied from 2 randomized controlled trials (RCTs),5 non-randomized experimental studies and 7 cohort studies were included. The results of meta-analysis demonstrated that intrauterine G-CSF infusion did improve endometrial thickness (MD=1.43,95%CI: 0.67 to 2.19,P=0.000 2),and increase clinical pregnancy rate (RR=2.48,95%CI: 1.37 to 4.51,P=0.003),and decrease the cycle cancellation rate (RR=0.44,95%CI: 0.29 to 0.66,P<0.000 1) compared with placebo or non-interfering control group. However,there was no statistically difference in embryo implantation rate (RR=1.90,95%CI: 0.99 to 3.67,P=0.05). Funnel plots showed a relatively low publication bias. Conclusions: The current data indicates that transvaginal intrauterine perfusion of G-CSF can improve endometrial thickness,clinical pregnancy rate and decrease the cycle cancellation rate. However,a larger number of well-designed studies are required to be verified.关键词
粒细胞集落刺激因子/薄型子宫内膜/体外受精-胚胎移植/临床妊娠率/Meta分析Key words
Granulocyte colony-stimulating factor/Thin endometrium/IVF-ET/Clinical pregnancy rate/Meta-analysis引用本文复制引用
谢易冉,田正平,张加苗,王婉雪,欧建平,杨一华..宫腔内灌注G-CSF对改善薄型子宫内膜临床疗效的系统评价与Meta分析[J].生殖医学杂志,2017,26(6):537-545,9.基金项目
国家自然科学基金(81560245,81360386) （81560245,81360386）
