生殖医学杂志2017，Vol.26Issue(6)：546-551,6.DOI:10.3969/j.issn.1004-3845.2017.06.008
精子DNA碎片指数阈值与体外受精-胚胎移植结局的相关性研究
Impact of threshold value of sperm DNA fragmentation on IVF-ET outcome
摘要
Abstract
Objective: To evaluate the correlation between the threshold value of sperm DNA fragment (SDF) and IVF-ET outcome. Methods: The clinical data were retrospectively analyzed. The patients were divided into three groups according to the set threshold value of SDF (10%,20% and 30%,respectively). Differences in semen routine parameters,acrosin activity,and IVF-ET outcome were compared among the three groups. Results: There was no significantly difference in semen routine parameters and acrosin activity among the three groups with the different SDF threshold value (10%,20% or 30%) (P>0.05). When SDF threshold value was set as 10%,there were no significantly differences in high quality embryo rate and clinical pregnant rate of IVF-ET between higher SDF group and lower SDF group (P>0.05). When the SDF threshold value was set as 20% or 30%,high-quality embryo rate and clinical pregnancy rate in higher SDF group were significantly lower than that in lower SDF group (P<0.05). The fertilization rate was also significantly decreased in higher SDF group when the threshold value was set as 30% (P<0.05). Conclusions: When the SDF threshold value was more than 20%,the higher SDF may have a negative impact on the assisted reproductive outcome of the patients. It is recommended to give appropriate anti-oxidative therapy. When the patient's sperm SDF is decreased to ≤20% after treatment,and then enters the IVF-ET cycle.关键词
精子DNA碎片指数/精液常规分析/顶体酶活力/IVF-ETKey words
Sperm DNA fragment/Semen routine parameter/Acrosin activity/IVF-ET引用本文复制引用
宋焱鑫,方东,赵芳,李红芳,张秦芳,张长兴,郭燕京,董波,郭杰,谷玉,姚晓飞,王宇刚,李岩,李静..精子DNA碎片指数阈值与体外受精-胚胎移植结局的相关性研究[J].生殖医学杂志,2017,26(6):546-551,6.基金项目
洛阳市科技局科技攻关项目(1302018B) （1302018B）
