生殖医学杂志2017，Vol.26Issue(6)：562-567,6.DOI:10.3969/j.issn.1004-3845.2017.06.011
来曲唑联合HMG准备子宫内膜在冻融胚胎移植中的应用
Letrozole combined with HMG for endometrial preparation in FET cycles
王凤 1龙惠东 1邓伟芬 1廖海珍 1黎雪玲 1张琴 1陈小梅1
作者信息
- 1. 深圳武警医院生殖中心,深圳 518000
- 折叠
摘要
Abstract
Objective: To explore the efficacy and safety of letrozole (LE) combined with HMG for endometrial preparation in frozen-thawed embryo transfer (FET) cycles. Methods: The data of FET cycles with different protocols for endometrial preparation in our center from July 2013 to June 2015 were retrospectively analyzed. There were 3 480 cycles using LE combined with HMG (LE group),940 natural cycles (nature group) and 1 495 artificial hormone replacement therapy (HRT) cycles (HRT group). Endometrium thickness and hormone levels on transforming day or HCG day were compared among the three different groups. Besides,embryo evaluation and cycle cancellation rate,FET outcomes (pregnancy rate,implantation rate and miscarriage rate) were also compared. Results:The cycle cancelation rate in the natural group (2.23%) was significantly higher than that in the other two groups (0.66%,0.74% respectively) (P<0.05). The mature follicle diameter on HCG day in LE group [(21.95±2.30) mm] were significantly larger than that in the natural group [(18.57±0.92) mm],but LH levels [(16.89±11.01) U/L] in LE group were significantly lower than those in natural group [(33.44±24.51) U/L] (P<0.05). The clinical pregnancy rate (61.85%) and live birth rate (49.46%) in LE group were significantly higher than the natural group (54.95%,42.76%) and HRT group (53.17%,39.35%) (P<0.05). The miscarriage rate in LE group (9.97%) was significantly lower than that in the natural group (19.21%) and the HRT group (11.91%) (P<0.05). Conclusions:LE combined with HMG for endometrial preparation in FET cycle is effective and safe. Its cancelation rate and miscarriage rate are lower,clinical pregnancy rate and live birth rate is higher. It is worthy of clinical promotion.关键词
来曲唑/人绝经期促性腺激素/冻融胚胎移植/子宫内膜准备Key words
Letrozole/HMG/FET cycles/Endometrium preparation引用本文复制引用
王凤,龙惠东,邓伟芬,廖海珍,黎雪玲,张琴,陈小梅..来曲唑联合HMG准备子宫内膜在冻融胚胎移植中的应用[J].生殖医学杂志,2017,26(6):562-567,6.
