天然产物研究与开发2017，Vol.29Issue(4)：590-594,5.DOI:10.16333/j.1001-6880.2017.4.010
极地真菌Geomyces sp.3-1次级代谢产物的研究
Secondary Metabolites of Polar-Derived Fungus Geomyces sp.3-1
摘要
Abstract
Eight compounds were obtained from the fermentation of the polar-derived fungus Geomyces sp.3-1.The extract was isolated and purified by column chromatography on silica-gel,reversed phase chromatography,Sephadex LH-20 and HPLC.The structures of compounds were elucidated by physical and chemical properties and spectral analysis,and comparison with the data of literatures.The eight compounds were identified as paulownin (1),demethylincisterol A3 (2),ergosta-7,22-dienen-3,6-dione (3),citreoanthrasteroid B (4),19-norergosta-5,7,9,22-tetraene-3β-ol (5),(22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol(6),(3β,5α,6β,22E)-6-methoxyergosta-7,22-diene-3,5-diol(7) and ergosta-7,22-dien-3β-ol (8).Compounds 2-7 were firstly isolated from Geomycesspecies,and compound 2 was shown to have antibacterial and cytotoxic activities.关键词
极地真菌/地丝霉属/次级代谢产物/生物学活性Key words
polar-derived fungus/Geomyces sp./secondary metabolites/biological activity分类
医药卫生引用本文复制引用
李云海,王晓丽,卢小玲,于豪冰,刘小宇..极地真菌Geomyces sp.3-1次级代谢产物的研究[J].天然产物研究与开发,2017,29(4):590-594,5.基金项目
广东省海洋局公益项目(GD2012-D01-001) （GD2012-D01-001）
国家自然科学基金(41306197,41606173) （41306197,41606173）
