天然产物研究与开发2017，Vol.29Issue(4)：629-634,6.DOI:10.16333/j.1001-6880.2017.4.017
连翘叶抗氧化谱效相关质量评价研究
Relationship Between HPLC Fingerprint Chromatogram and Antioxidant Activity of Forsythia suspense Leaves
摘要
Abstract
A spectrum-effect correlation pattern was developed to evaluate the antioxidant activity and the main active components of Forsythia suspense leaves in this study.The fingerprint chromatogram of the 18 Forsythia suspense leaves extracts collected from different places was established by HPLC.In addition the antioxidant activity and the content of total phenol of these 18 extracts were studied using the 1,1-diphenyl-2-picrylhydrazyl free radical(DPPH ·)-scavenging method and Folin-Ciocalteuas method,respectively.The results showed that the antioxidant activity was correlated to the content of total phenol by the analysis of bivariate correlation.Furthermore,three components played a role in antioxidant activity of F.suspense leaves through the analysis of principal component,bivariate correlation and multiple linear regression.The study provided reference for the evaluation of antioxidant activity of F.suspense leaves.关键词
连翘叶/指纹图谱/抗氧化/谱效相关Key words
Forsythia suspense leaves/fingerprint/antioxidant activity/spectrum-effect correlation pattern分类
医药卫生引用本文复制引用
张元波,张敏,程启斌,马丽莎,张立伟..连翘叶抗氧化谱效相关质量评价研究[J].天然产物研究与开发,2017,29(4):629-634,6.基金项目
山西省国际合作项目(2014081049-1) （2014081049-1）
山西省科学技术发展计划(2014ZD00402) （2014ZD00402）
