天然产物研究与开发2017，Vol.29Issue(4)：653-657,5.DOI:10.16333/j.1001-6880.2017.4.021
恒山黄芪多糖对人宫颈癌细胞SiHa的抑制效应分析
Inhibitory Effect of Hengshan Astragalus Polysaccharides on Human Cervical Cancer Cell SiHa
摘要
Abstract
To evaluate the effects of Hengshan Astragalus polysaccharides on human cervical cancer cell SiHa,MTT assay was used to determine cell proliferation and viability of SiHa.The cell adhesive assay and cell spreading assay were used to detect the adhesive and spreading capabilities of SiHa,and the wound-healing assay was used to access the migration capability of SiHa.The results indicated that Hengshan Astragalus polysaccharides showed significant activity of suppressing SiHa cell proliferation (ICs0 value was 0.25 mg/mL) even at a low concentration (0.0625 mg/mL).Compared with the control group,the adhesive and spreading capability of SiHa cells treated with Hengshan Astragalus polysaccharides were obviously reduced (P ＜ 0.0l),and the migration capability was also depressed remarkably (P ＜ 0.01).Therefore,polysaccharides from the genuine medicinal material Hengshan Astragalus can inhibit the proliferation,adhesion,spreading and migration capability of human cervical cancer cell SiHa.关键词
恒山黄芪/多糖/肿瘤细胞/粘附/铺展/迁移Key words
Hengshan Astragalus/polysaccharides/cancer cells/cell adhesion/cell spreading/cell migration分类
医药卫生引用本文复制引用
李平,胡建燃,铁军..恒山黄芪多糖对人宫颈癌细胞SiHa的抑制效应分析[J].天然产物研究与开发,2017,29(4):653-657,5.基金项目
山西省“服务产业创新学科群”培育项目 （）
山西省高校创新学科群项目子项目(XKQZXM200601) （XKQZXM200601）
