中国保健营养2017，Vol.27Issue(15)：5-6,2.
脑出血小鼠模型血肿周围Nogo-A通路表达研究
The expression of Nogo-A and NgR protein around the hematoma in intracerebral hemorrhage mouse model
张建新 1朱孔江1
作者信息
- 1. 炮兵第七十九旅(原65659部队)医院,辽宁 锦州 121000
- 折叠
摘要
Abstract
Objective The investigate the expression of Nogo-A protein and it's receptor NgR around the hematoma in intracerebral hemorrhage mouse model.Methods Using stereotaxic technique to inject autologous blood into the caudate putamen to establish intracerebral hemorrhage mouse model.WesternBlot and immunohistochemical methods was used to detect the Nogo-A and NgR expression level in the tissue around the hematoma.Results The Nogo-A and NgR expression were significantly upregulated after 3d of ICH.Conclusion The effect of inhibition axon growth throw the Nogo-A signal pathway was enhancement after ICH,so it's reasonable to speculate that anti-Nogo-A signal pathway may serve as therapeutic targets for cerebral hemorrhage.关键词
脑出血/Nogo-A/NgRKey words
Intracerebral hemorrhage/Nogo-A/NgR分类
医药卫生引用本文复制引用
张建新,朱孔江..脑出血小鼠模型血肿周围Nogo-A通路表达研究[J].中国保健营养,2017,27(15):5-6,2.
