中国当代儿科杂志2017，Vol.19Issue(6)：632-637,6.DOI:10.7499/j.issn.1008-8830.2017.06.005
不同胎龄早产儿生后早期对脂肪乳的耐受性研究
Fat emulsion tolerance in preterm infants of different gestational ages in the early stage after birth
摘要
Abstract
Objective To investigate the fat emulsion tolerance in preterm infants of different gestational ages in the early stage after birth. Methods A total of 98 preterm infants were enrolled and divided into extremely preterm infant group (n=17), early preterm infant group (n=48), and moderate-to-late preterm infant group (n=33). According to the dose of fat emulsion, they were further divided into low- and high-dose subgroups. The umbilical cord blood and dried blood filter papers within 3 days after birth were collected. Tandem mass spectrometry was used to measure the content of short-, medium-, and long-chain acylcarnitines. Results The extremely preterm infant and early preterm infant groups had a significantly lower content of long-chain acylcarnitines in the umbilical cord blood and dried blood filter papers within 3 days after birth than the moderate-to-late preterm infant group (P<0.05), and the content was positively correlated with gestational age (P<0.01). On the second day after birth, the low-dose fat emulsion subgroup had a significantly higher content of short-, medium-, and long-chain acylcarnitines than the high-dose fat emulsion subgroup among the extremely preterm infants (P<0.05). In the early preterm infant and moderate-to-late preterm infant groups, there were no significant differences in the content of short-, medium-, and long-chain acylcarnitines between the low- and high-dose fat emulsion subgroups within 3 days after birth. Conclusions Compared with moderate-to-late preterm infants, extremely preterm infants and early preterm infants have a lower capacity to metabolize long-chain fatty acids within 3 days after birth. Early preterm infants and moderate-to-late preterm infants may tolerate high-dose fat emulsion in the early stage after birth, but extremely preterm infants may have an insufficient capacity to metabolize high-dose fat emulsion.关键词
脂肪乳/代谢组学/酰基肉碱/串联质谱/早产儿Key words
Fat emulsion/Metabolomics/Acylcarnitine/Tandem mass spectrometry/Preterm infant引用本文复制引用
唐慧,袁瑞琴,朱小瑜,杨传忠,李欢,文伟,黄芳芳,黄智峰,石玉萍,余彦亮,陈丽莲..不同胎龄早产儿生后早期对脂肪乳的耐受性研究[J].中国当代儿科杂志,2017,19(6):632-637,6.基金项目
深圳市科技计划项目(201201025). （201201025）
