中国当代儿科杂志2017，Vol.19Issue(6)：646-651,6.DOI:10.7499/j.issn.1008-8830.2017.06.007
辅助生殖技术出生儿童的青春发育情况调查
A survey of pubertal development in children born with assisted reproductive technology
刘子源 1王新利 1韩彤妍 1崔蕴璞 1王雪梅 1童笑梅 1宋逸 2王海俊 2李松1
作者信息
- 1. 北京大学第三医院儿科,北京 100191
- 2. 北京大学儿童青少年卫生研究所,北京 100191
- 折叠
摘要
Abstract
Objective To investigate the status of pubertal development in children born with assisted reproductive technology (ART). Methods A retrospective analysis was performed on the pubertal development data of children born with ART in Peking University Third Hospital from 1994 to 2003 (ART group). The data in the cross-sectional study "Reports on the Physical Fitness and Health Research of Chinese School Students in 2010" were used as a control. The age at menarche and the age at spermarche were compared between the two groups. The status of pubertal development in the overweight and obese children in the ART group was evaluated to investigate the correlation between pubertal development and body mass index (BMI). Results A total of 200 children born with ART were enrolled in this study, and 72 of them (41 males and 31 females) completed the survey (response rate=36.0%). In the ART group, the mean age at spermarche and the mean age at menarche were 13.9 years (95%CI: 13.7-14.3 years) and 12.2 years (95%CI: 11.8-12.6 years), respectively. There were no significant differences in the age at spermarche and the age at menarche between the ART and control groups (P>0.05). In the ART group, there were no significant differences in the age at spermarche and the age at menarche between the overweight and obese children and the normal weight children (P>0.05). There were also no significant differences in overweight rate and obesity rate between the children in the ART group and the adolescents in Beijing (P>0.05). In the ART group, there was no significant correlation between the age at spermarche or menarche and BMI (P>0.05). Conclusions No delayed or precocious puberty is observed in children born with ART. This is consistent with the normal control data. And there is no significant correlation between pubertal development and BMI in children born with ART.关键词
辅助生殖技术/青春发育/首次遗精/月经初潮/儿童Key words
Assisted reproductive technology/Pubertal development/Spermarche/Menarche/Child引用本文复制引用
刘子源,王新利,韩彤妍,崔蕴璞,王雪梅,童笑梅,宋逸,王海俊,李松..辅助生殖技术出生儿童的青春发育情况调查[J].中国当代儿科杂志,2017,19(6):646-651,6.
