中国当代儿科杂志2017，Vol.19Issue(6)：724-729,6.DOI:10.7499/j.issn.1008-8830.2017.06.021
线粒体自噬与神经系统疾病
Mitophagy and nervous system disease
摘要
Abstract
Mitophagy is a process during which the cell selectively removes the mitochondria via the mechanism of autophagy. It is crucial to the functional completeness of the whole mitochondrial network and determines cell survival and death. On the one hand, the damaged mitochondria releases pro-apoptotic factors which induce cell apoptosis; on the other hand, the damaged mitochondria eliminates itself via autophagy, which helps to maintain cell viability. Mitophagy is of vital importance for the development and function of the nervous system. Neural cells rely on autophagy to control protein quality and eliminate the damaged mitochondria, and under normal circumstances, mitophagy can protect the neural cells. Mutations in genes related to mitophagy may cause the development and progression of neurodegenerative diseases. An understanding of the role of mitophagy in nervous system diseases may provide new theoretical bases for clinical treatment. This article reviews the research advances in the relationship between mitophagy and different types of nervous system diseases.关键词
线粒体自噬/神经系统疾病/脑损伤/神经退行性病变Key words
Mitophagy/Nervous system disease/Brain damage/Neurodegenerative disease引用本文复制引用
李明熹..线粒体自噬与神经系统疾病[J].中国当代儿科杂志,2017,19(6):724-729,6.基金项目
国家自然科学基金(81330016, 81300526) （81330016, 81300526）
国家重点基础发展计划(973 计划)(2013CB967404) （973 计划）
四川省科技计划项目(2014SZ0149) （2014SZ0149）
临床重点专科计划项目(1311200003303). （1311200003303）
