中国动脉硬化杂志2017，Vol.25Issue(5)：485-489,5.
遵义汉族人群载脂蛋白A5基因多态性与高胆固醇血症的关系
Association of apolipoprotein A5 gene polymorphism with hyper total cholesterolemia of the Han Nationality in Zunyi
摘要
Abstract
Aim To investigate the relativity of apolipoprotein A5 gene (ApoA5) c.553G/T polymorphism in exon 4 with hyper total cholesterolemia (HTC) in Zunyi Han Nationality.Methods c.553G/T polymorphism of 101 HTC patients and 118 healthy individuals were tested by polymerase chain reaction and restriction fragment length (PCRRFLP) assay.Results The genotype frequency of ApoA5 gene c.553G/T showed statistically difference between patients group and normal groups (P＜0.05),and the distribution of ApoA5 c.553T gene in HTC group was significantly higher than normal group (P＜ 0.05),therefore it had independent effect on HTC (OR =4.685,95％ CI:1.269 ～ 17.296,P =0.020).It has more optical clinical significance comparing different blood lipid index ratio than one blood lipid index.Conclusion There was relativity between ApoA5 gene c.553G/T polymorphism and HTC in Zunyi Han Nationality.The c.553T gene was an independent risk factor for HTC.关键词
载脂蛋白A5基因/c.553G/T位点多态/高胆固醇血症/遵义汉族人群/血脂指标比值Key words
Apolipoprotein A5 gene/c.553G/T polymorphism/Hyper total cholesterolemia/Zunyi Han nationality/Blood lipid index ratio分类
医药卫生引用本文复制引用
肖代敏,耿争光,杨昌伟,李春霞,张志敏..遵义汉族人群载脂蛋白A5基因多态性与高胆固醇血症的关系[J].中国动脉硬化杂志,2017,25(5):485-489,5.基金项目
贵州省科技厅项目(黔科合J字LKZ[2012]39号) （黔科合J字LKZ[2012]39号）
遵义医学院大学生创新创业训练计划项目(院发[2014]5828) （院发[2014]5828）
