中国动脉硬化杂志2017，Vol.25Issue(5)：513-518,6.
脂蛋白脂酶降解与代谢异常性疾病
Lipoprotein lipase degradation and metabolic disorders
摘要
Abstract
Lipoprotein lipase (LPL) degradation is one of the important ways to regulate the level of LPL.Recently,it has been found that LPL degradation is regulated by a variety of related proteins,the process of LPL degradation mainly includes two parts:intracellular degradation and extracellular degradation.The intracellular degradation of LPL means a large amount of newborn LPL which were transferred to the lysosome for degradation via the related proteins.The extracellular degradation of LPL means mature LPL which were re-uptaked or transported into the cell under the action of the related proteins,and then gathered into lysosomal for degradation.This article will review the LPL in the process of LPL protein synthesis,transportation and biological functions,and then elucidate the relationship between its degradation and metabolic syndrome.关键词
脂蛋白脂酶/溶酶体降解/动脉粥样硬化/糖尿病心肌病/肥胖Key words
Lipoprotein lipase/Lysosomes degradation/Atherosclerosis/Diabetic cardiomyopathy/Obesity分类
医药卫生引用本文复制引用
成海鹏,尹卫东,唐朝克..脂蛋白脂酶降解与代谢异常性疾病[J].中国动脉硬化杂志,2017,25(5):513-518,6.基金项目
国家自然科学基金项目(81270269、81370377、81570408) （81270269、81370377、81570408）
南华大学分子靶标新药研究协同创新中心研究生创新性实验项目(0223-0002-D0033) （0223-0002-D0033）
