中国全科医学2017，Vol.20Issue(18)：2183-2187,5.DOI:10.3969/j.issn.1007-9572.2017.04.y08
自噬在慢性阻塞性肺疾病发病机制中的作用及其研究进展
Recent Developments in Autophagy in the Pathogenesis of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Chronic obstructive pulmonary disease(COPD) is a progressive and irreversible lung disease due to airflow limitation with high disability and morbidity rates.Autophagy is a degradation process of cytoplasmic proteins and organelles through lysosomal pathway,in which the damaged cell structure,aging organelles and no longer needed biomacromolecules are cleaned out.Recently,it has been found that autophagy is closely related to the pathogenesis of COPD,and the autophagy activity is enhanced in COPD patients.In this paper,the recent developments in the role of autophagy in airway,pulmonary vascular disease and lung parenchyma is reviewed.关键词
肺疾病/慢性阻塞性/自噬Key words
Pulmonary disease/chronic obstructive/Autophagy分类
医药卫生引用本文复制引用
蒋明,王鹏雁..自噬在慢性阻塞性肺疾病发病机制中的作用及其研究进展[J].中国全科医学,2017,20(18):2183-2187,5.基金项目
国家自然科学基金资助项目(81360010) （81360010）
广西壮族自治区卫生厅重点科研基金资助项目(重2012004) （重2012004）
