中国实用内科杂志2017，Vol.37Issue(5)：456-459,4.DOI:10.19538/j.nk2017050134
血糖正常人群的胰岛素分泌及敏感性与2型糖尿病遗传背景遗传强度的相关性研究
A cross-section study of the relation of genetic background and genetic intensity of type 2 diabetes to insulin secretion and sensitivity in people with normal blood glucose
摘要
Abstract
Objective To evaluate the glucose tolerance status of residents in Shanghai and the effects of different genetic background and intensity on insulin secretion and insulin resistance in subjects with family history of type 2 diabetes(T2DM).Methods Epidemiological questionnaires,physical examination and OGTT were performed in residents in many communities in Shanghai.Homeostasis model and Gutt-ISI were calculated by the level of blood glucose and insulin to assess the insulin secretion and sensitivity in the community with normal blood glucose in many communities in Shanghai.Results (1) The incidence of T2DM was 6.51％ (19 cases),impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) was 12.67％ (37 cases) at all in the 292 subjects.(2) As the SNK and t test analysis showed,the average numbers of Insulin sensitivity was worse in subjects with positive family history of T2DM than those without family history (HOMA-IS:male 0.52±0.17 vs.0.54±0.28,female 0.59±0.30 vs.0.69±0.33,P=0.04),the mean level of secretion function of islet B cells was significantly higher than that without family history (HOMA-β:male 190.6±130.31 vs.142.58±76.06,female 157.84±96.68 vs.120.87±74.71,P=0.02).(3) There were significant differences both in the insulin sensitivity and B cell secretory function in the subjects with siblings of T2DM than those with paternal inheritance,maternal inheritance and parental inheritance (P＜0.05).Meanwhile,the insulin sensitivity was declined with the severity of genetic background of T2DM,and the level of HOMA-β was positively correlated with the genetic background (P＜0.05).Conclusion Subjects with family history of T2DM has an obvious decrease of insulin sensitivity in the early stage of normal blood glucose specially with siblings of T2DM.The candidates' insulin sensitivities decreased with the worse of genetic intensity.Therefore,the islet B cells,in order to maintain the normal blood glucose,have to compensate the secretion.关键词
2型糖尿病/胰岛B细胞功能/胰岛素敏感性Key words
type 2 diabetes mellitus/β cell function/insulin sensitivity分类
医药卫生引用本文复制引用
陆晓敏,闾倩,宋艳,陈娟,廖小娴,李拓,石勇铨..血糖正常人群的胰岛素分泌及敏感性与2型糖尿病遗传背景遗传强度的相关性研究[J].中国实用内科杂志,2017,37(5):456-459,4.基金项目
上海市卫生与计划生育委员会公共卫生3年行动计划重点项目 （）
