中国心理卫生杂志2017，Vol.31Issue(5)：337-344,8.DOI:10.3969/j.issn.1000-6729.2017.05.001
精神分裂症幻听的静息态脑网络研究
Dysconnectivity of multiple resting-state networks in patients with schizophrenia with auditory verbal hallucinations
摘要
Abstract
Objective:To explore the traits of functional connectivity of resting-state networks in patients of schizophrenia with auditory verbal hallucinations (AVH) by using independent component analysis (ICA).Methods:All patients were met the Diagnostic and Statistical Mannal of Mental Disorders,Fourth Edition,Text Revision (DSM-IV-TR) diagnostic criteria for schizophrenia.Thirty schizophrenia patients with frequent AVH (AVH),24 schizophrenia patients without AVH (non-AVH) and 60 healthy controls (HC) matching with age and gender were analyzed by resting functional magnetic resonance imaging.The AVH were assessed by using Hoffman auditory hallucination scale.By using ICA,auditory network (AUN),language network (LAN),salience network (SAN),right front-parietal network (RFP) and default mode network (DMN) were selected as interesting networks for further analyses.Covariance analysis was used to compare the activity and functional connectivity of multiple resting state networks between three groups,and correlation analysis was used to evaluate the relations between abnormalities of brain and the severity of hallucination.Results:Compared to non-AVH,AVH group showed increased activity in left superior temporal gyrus (STG) and left postcentral gyrus (LPG) in the AUN,and showed decreased activity in right anterior cingulate cortex (ACC) in the SAN (P ＜ 0.05,FDR corrected).The severity of AVH group was associated with activity of the left STG (r =0.43,P ＜0.05) and the right ACC (r =-0.48,P ＜0.01).Furthermore,compared to non-AVH group,there were decreased connectivity between LAN and AUN [(-0.29 ±0.21) vs.(-0.16 ± 0.17),P ＜ 0.05,uncorrected],decreased connectivity between SAN and LAN [(-0.09 ± 0.22) vs.(-0.06 ± 0.18),P ＜ 0.05,uncorrected],increased connectivity between SAN and AUN [(0.30 ± 0.18) vs.(0.15 ± 0.24),P ＜ 0.05,uncorrected] in AVH group.Conclusion:There may be aberrant functional connectivities of AUN,LAN and SAN in schizophrenia patients with frequent AVH,and the occurrence of AVH seems to be related to brain areas involved in language production,speech perception and self-monitoring.关键词
精神分裂症/幻听/静息态脑网络/独立成分分析/功能磁共振成像Key words
schizophrenia/auditory verbal hallucinations/resting-state networks/independent component analysis/functional magnetic resonance imaging分类
医药卫生引用本文复制引用
廖金敏,刘琦,姜思思,张晓,董铮,蔡丽伟,闫俊,张岱,阎浩..精神分裂症幻听的静息态脑网络研究[J].中国心理卫生杂志,2017,31(5):337-344,8.基金项目
国家科技支撑计划“基于临床医学研究协同网络的情感认知障碍综合诊疗关键技术研究”(2015BAI13B01),科技部国家“973”计划项目子课题“弥漫性脑损害(精神分裂症)的脑网络研究”(2011CB707805) （2015BAI13B01）
