中国心理卫生杂志2017，Vol.31Issue(5)：345-349,5.DOI:10.3969/j.issn.1000-6729.2017.05.002
首发精神分裂症患者和精神病高危者的认知功能
Cognitive function in patients with first-episode schizophrenia and individuals at high-risk for psychosis
摘要
Abstract
Objective:To explore the characteristics of cognitive function in first episode patients (FES),ultra-high risk subjects (UHRs) and non-psychotic first-degree relatives of schizophrenia (FDRs),in comparison with healthy controls (HCs).Methods:Forty-one FES patients which met the Diagnostic and Statistical Manual of Mental Disorders,the Fourth Edition (DSM-Ⅳ) criteria for schizophrenia,31 UHRs which met the Structured Interview for Psychosis-risk Syndromes (SIPS),25 FDRs of patients with schizophrenia (unrelated to the FES group),and 27 HCs were recruited.They were assessed with the connection test (TMTA),symbol coding,hopkins verbal learning test revision (HVLT),continuous performance test (CPT),and Stroop color-word test for evaluation of cognitive function.Results:After controlling for basic demographic characteristics including age,gender and educational level,there was a significant difference between FES,FDRs,UHRs and HCs with respect to TMTA (F =11.45,P ＜ 0.001),symbol encoding (F =11.69,P ＜ 0.001),HVLT-R(F =5.34,P ＜ 0.05),Stroop word test (F =2.79,P ＜ 0.05),Stroop color test F =3.73,P ＜ 0.05),Stroop color-word test (F =3.83,P ＜ 0.05) and the CPT test (F =13.62,P ＜ 0.05).FES patients performed worse than FDRs,UHRs,or HCs.FDRs performed better than UHRs in the following tests (Ps ＜ 0.05).Conclusion:The severity of cognitive impairments is associated with the risk of developing schizophrenia.关键词
首发精神分裂症/认知功能/患者一级亲属/超高危Key words
first episode schizophrenia/cognitive functions/first-degree relatives of schizophrenia/Ultra high risk for psychosis分类
医药卫生引用本文复制引用
张哲,周福春,何凡,杨宁波,张梁,王传跃..首发精神分裂症患者和精神病高危者的认知功能[J].中国心理卫生杂志,2017,31(5):345-349,5.基金项目
国家自然基金面上项目(81471365),卫生行业科研专项(201002003),北京市科技计划项目(D121100005012004),北京市医院管理局临床医学发展专项经费资助(ZYLX201403) （81471365）
