中国药房2017，Vol.28Issue(16)：2259-2261,3.DOI:10.6039/j.issn.1001-0408.2017.16.27
阿德福韦酯纳米脂质载体的制备及处方优化
Preparation and Formulation Optimization of Nanostructured Lipid Carriers of Adefovir Dipivoxil
摘要
Abstract
OBJECTIVE:To prepare nanostructured lipid carrier of adefovir dipivoxil(ADV-NLC),and optimize the formula-tion. METHODS:Using stearic acid and glycerin monostearate as solid lipid,oleic acid as liquid lipid,Gemini surfactant and poly-sorbate 80 as emulsifier,sodium dodecyl sulfate (SDS) as stabilizer,solvent dispersion ultrasonic method was used to prepare ADV-NLC. And using particle size,polydispersity index,Zeta potential,encapsulation efficiency as indexes,single factor test was conducted to screen Gemini surfactant-polysorbate 80 ratio,emulsifier dosage(ratio of emulsifier to water phase),drug-lipid ratio, solid-liquid lipid ratio. RESULTS:The formula was as follow as 3% emulsifier (Gemini surfactant-polysorbate 80 ratio of 1:2), 4.5% drug-lipid ratio,solid-liquid lipid ratio of 6:5. The average particle size of the prepared ADV-NLC was(48.83±2.65)nm, polydispersity index<0.3,Zeta potential was(-28.7±1.8)mV,encapsulation efficiency was(77.65±0.03)%(n=3). CONCLU-SIONS:ADV-NLC is successfully prepared,and the formulation is reasonable and feasible.关键词
阿德福韦酯/纳米脂质载体/双子表面活性剂/处方优化Key words
Adefovir dipivoxil/Nanostructured lipid carrier/Gemini surfactant/Formulation optimization分类
医药卫生引用本文复制引用
孙珊珊,王慧云,王飞飞,丁林..阿德福韦酯纳米脂质载体的制备及处方优化[J].中国药房,2017,28(16):2259-2261,3.基金项目
济宁医学院科研计划项目(No.JY2013KJ010) （No.JY2013KJ010）
