中国医科大学学报2017，Vol.46Issue(5)：388-391,4.DOI:10.12007/j.issn.0258⁃4646.2017.05.002
晚期糖基化终末产物在多囊卵巢综合征大鼠模型中的表达
Expression of Advanced Glycation End Products in a Rat Model of Polycystic Ovarian Syndrome
摘要
Abstract
Objective To investigate the expression of advanced glycation end products(AGEs)in a rat model of polycystic ovarian syndrome (PCOS)induced by dehydroepiandrosterone. Methods The PCOS rat model was established using dehydroepiandrosterone . After confirming that the model rats were set up successfully,serum AGEs concentrations were measured using competitive ELISA and the expression of AGEs in the ovarian tissues of these rats was detected using immunohistochemistry. Results The serum AGEs level in the experimental group were signifi?cantly higher than that in the control group(P<0.05). Furthermore,AGEs expression were significantly higher in the experimental group than in the control group(P<0.01). Conclusion AGEs are highly expressed in the rat PCOS model,signifying their importance in the diagnosis and pathogenesis of PCOS.关键词
多囊卵巢综合征/晚期糖基化终产物/大鼠Key words
polycystic ovarian syndrome/advanced glycation end products/rat分类
医药卫生引用本文复制引用
赵彦楠,刘洪祥,霍佳宁,马晓欣..晚期糖基化终末产物在多囊卵巢综合征大鼠模型中的表达[J].中国医科大学学报,2017,46(5):388-391,4.基金项目
国家自然科学基金(81472438,81272874) （81472438,81272874）
辽宁省科学技术计划(2013225079) （2013225079）
沈阳市科学技术项目( F14?158?9?47) （ F14?158?9?47）
