中国医科大学学报2017，Vol.46Issue(5)：406-408,412,4.DOI:10.12007/j.issn.0258⁃4646.2017.05.006
注射异丙肾上腺素建立大鼠心肌肥厚模型
Rat Model of Isoproterenol?induced Cardiac Hypertrophy
摘要
Abstract
Objective To establish a rat model of cardiac hypertrophy induced by isoproterenol(ISO),and to study its basic characteristics . Methods Cardiac hypertrophy was induced in rats with ISO. The model rats received subcutaneous injections of 5 mg/kg ISO every day for 14 days. Results The heart weight/body weight and left ventricular weight/body weight ratios in model rats were significantly increased. The serum hydroxyproline level was significantly increased ,the superoxide dismutase level was significantly decreased ,and the malondialdehyde level was sig?nificantly increased in model rats. Conclusion The rat model of cardiac hypertrophy is successfully created by subcutaneous injection of ISO for 14 days. This model can be used in study of the mechanism of cardiac hypertrophy.关键词
心肌肥厚/异丙肾上腺素/动物模型Key words
cardiac hypertrophy/isoproterenol/animal model分类
医药卫生引用本文复制引用
赵美眯,李卓,杨艳,张翀翯,陈思充,曾晓荣,郝丽英..注射异丙肾上腺素建立大鼠心肌肥厚模型[J].中国医科大学学报,2017,46(5):406-408,412,4.基金项目
国家自然科学基金(31500930,31471091) （31500930,31471091）
医学电生理学重点实验室开放基金(KeyME?2014?03) （KeyME?2014?03）
