中国医科大学学报2017，Vol.46Issue(5)：409-412,4.DOI:10.12007/j.issn.0258⁃4646.2017.05.007
不同剂量舒芬太尼在全麻诱导气管插管时对定量药物脑电图α1频段的影响
Effects of Different Doses of Sufentanil on α1?band of Quantitative Pharmaco?electroencephalography during General Anesthesia Induction by Tracheal Intubation
摘要
Abstract
Objective To compare the effects of different doses of sufentanil on theα1?band of quantitative pharmaco?electroencephalography (QPEEG)during the induction of general anesthesia by tracheal intubation(TI). Methods Forty selected patients under general anesthesia were randomly divided into two groups,with 20 patients per group. Patients in group Ⅰ were administered 0.2μg/kg sufentanil,whereas patients in group Ⅱ were administered 0.3μg/kg sufentanil. Subsequently,the patients were administered 2 mg/kg propofol and 0.15 mg/kg cisatracurium. HR,MAP,and QPEEG were recorded before induction(T0),after induction(T1),and after insertion of the cannula(T2). Using the method of power spectrum analysis,theα1?band power percentage of QPEEG was calculated. Results In comparison with T0,the values of HR,MAP,andα1?band power percentage in most areas of the brain were both decreased at T1(P<0.05). Furthermore,in comparison with T1,the parameters were increased in group Ⅰ at T2(P<0.05),but no significant changes were observed in group Ⅱ (P>0.05). Conclusion The administration of 0.3μg/kg sufentanil during anesthesia induction can effectively depress the cardiovascular response to TI and stabilize theα1?band power per?centage. This suggests that theα1?band power percentage of QPEEG can be an effective means to monitor the depth of sedation.关键词
舒芬太尼/气管插管/定量药物脑电图/α1频段Key words
sufentanil/tracheal intubation/quantitative pharmaco⁃electroencephalography/α1⁃band分类
医药卫生引用本文复制引用
李阳,李秀艳,曹悦悦,王宏玉,麻婷婷,朱俊超..不同剂量舒芬太尼在全麻诱导气管插管时对定量药物脑电图α1频段的影响[J].中国医科大学学报,2017,46(5):409-412,4.基金项目
国家自然科学基金(81401231) （81401231）
