中国医科大学学报2017，Vol.46Issue(6)：485-488,4.DOI:10.12007/j.issn.0258⁃4646.2017.06.002
miR⁃135a⁃5p在子宫内膜癌中的表达及意义
Expression and Significance of miR?135a?5p in Endometrial Carcinoma
摘要
Abstract
Objective To investigate the expression and significance of miR?135a?5p in endometrial carcinoma and to correlate expression levels with clinicopathological features. Methods Fifty five endometrial carcinoma samples and thirty normal endometrial tissue samples were surgically obtained,and the expression of miR?135a?5p was quantitated by real?time polymerase chain reaction. The relationship between the expression level of miR?135a?5p and clinicopathological data of individual patients was analyzed. Results The expression of miR?135a?5p was lower in the endo?metrial carcinoma group than in the normal endometrial group(P=0.021),and correlated significantly with the histologic grade of the endometrial neoplasm(P=0.008). Conclusion The expression of miR?135a?5p is lower in endometrial carcinoma than in normal endometrial tissue. In en?dometrial carcinoma,the miR?135a?5p expression status has a statistically significant relationship with the histological characteristics of the tumor.关键词
miR⁃135a⁃5p/子宫内膜癌/表达Key words
miR⁃135a⁃5p/endometrial carcinoma/expression分类
医药卫生引用本文复制引用
冷洪锐,孔繁菲,马晓欣..miR⁃135a⁃5p在子宫内膜癌中的表达及意义[J].中国医科大学学报,2017,46(6):485-488,4.基金项目
国家自然科学基金(81472438,81272874) （81472438,81272874）
辽宁省科学技术计划(2013225079) （2013225079）
