中国医学前沿杂志（电子版）2017，Vol.9Issue(4)：31-35,5.DOI:10.12037/YXQY.2017.04-08
急性脑出血患者血肿周围组织IL-17和NF-κBp65的表达及意义
Expression and significance of IL-17 and NF-κBp65 in the tissues around hematoma of patients with acute cerebral hemorrhage
摘要
Abstract
Objective To investigate the expression and significance of interleukin-17 (IL-17) and nuclear factor-κBp65 (NF-κBp65) in the tissues around hematoma in patients with acute intracerebral hemorrhage. Method 60 samples from the tissues around hematoma with acute intracerebral hemorrhage in our hospital from January 2015 to December 2015 were selected, according to the different onset to peration time, they were divided into<6 hours group,≥6 hours and≤24 hours group,>24 hours and≤72 hours group, and>72 hours group. Another 15 samples away from the hematoma were selected as control group. The expression levels of IL-17 and NF-κBp65 were detected by immunohistochemistry, polymerase chain reaction and Western blotting.Result The expression levels of IL-17 and NF-κBp65 were higher in patients with acute cerebral hemorrhage. And the positive rate of IL-17 and NF-κBp65 cells increasedfirst and then decreased with the prolongation of bleeding time. The expression level of IL-17 between<6 hours group and control group had no significant difference. However, the expressions of IL-17 mRNA in the other groupswere higher than control group (P<0.01). Especially, the expression of IL-17 mRNA in>24 hours group and≤72 hours group was the highest. The expression levels of NF-κBp65 in≥6 hours and≤24 hours group,>24 hours and≤72 hours group,>72 hours group were significantly higher than that of control group (P<0.01). Especially, the expression level of NF-κBp65 in>24 hours and≤72 hours group was thehighest.Conclusion The expression level of IL-17 and NF-κBp65 in the tissues around hematoma with acute intracerebral hemorrhage significantly increased. The onset to operation time of>24 hours and≤72 hours is the most obvious.关键词
急性脑出血/周围组织/白介素-17/核因子-κBp65Key words
Acute cerebral hemorrhage/Surrounding tissue/Interleukin-17/Nuclear factor-κBp65引用本文复制引用
于泽奇,李怀康,王婧怡,苟莞苓..急性脑出血患者血肿周围组织IL-17和NF-κBp65的表达及意义[J].中国医学前沿杂志（电子版）,2017,9(4):31-35,5.基金项目
国家自然科学基金项目(31200809) （31200809）
武警部队后勤科研项目(WJHQ2012-20) （WJHQ2012-20）
军队技术产品研究重大项目(AWS15J001) （AWS15J001）
天津市科技计划项目(15ZXLCSY00040) （15ZXLCSY00040）
