中国肿瘤生物治疗杂志2017，Vol.24Issue(5)：461-466,6.DOI:10.3872/j.issn.1007-385X.2017.05.001
改进CAR-T细胞有效性和安全性的设计策略
The design strategies for improving the efficacy and safety of CAR-T cells
摘要
Abstract
The chimeric antigen receptor T cells (CAR-T cells) have entered to clinical trials from laboratories,which have achieved a remarkable effect in treatment of the B cell malignancy.But a lot of difficulties and challenges were still faced in the clinical researches on exploring treatment of the CAR-T cells for malignant tumors.It is difficult to find specific targets of the tumors and to overcome on-target off tumor effect.In the treatment of solid tumors,the CAR-T cells hard to reach the tumor positions and to improve their immunosuppressive microenvironment.When the CAR-T cells eliminate tumor cells,at the same time they also kill normal cells with the same target points.Efficacy of the CAR-T cells therapy for hematologic tumors and solid tumors except B cell tumors still needs to be improved.This paper focuses on that how the CAR-T cells could accurately identify tumor cells via optimization of the CAR-T cell structures and that effectiveness of the CAR-T cell therapy for malignant tumors could be enhanced through overcoming immunosuppressive microenvironment of tumors.At the same time,the CAR-T cells could be better controlled and safety of the CAR-T cells higher.关键词
CAR-T细胞/设计策略/结构改造/有效性/安全性Key words
CAR-T cell/design strategy/structural modification/effectiveness/safety分类
医药卫生引用本文复制引用
张昂,张斌,陈虎..改进CAR-T细胞有效性和安全性的设计策略[J].中国肿瘤生物治疗杂志,2017,24(5):461-466,6.基金项目
首都临床特色应用研究与成果推广项目(No.Z161100000516184).Project supported by the Application Research and Achievement Promotion of Clinical Characteristics in the Capital City (No.Z161100000516184) （No.Z161100000516184）
