中国卒中杂志2017，Vol.12Issue(6)：477-483,7.DOI:10.3969/j.issn.1673-5765.2017.06.003
脑微出血与急性缺血性卒中溶栓后出血转化的相关性研究
Study on Correlation between Cerebral Microbleeds and Hemorrhagic Transformation after Thrombolytic Therapy in Acute Ischemic Stroke
摘要
Abstract
Objective To analyze the correlation between cerebral microbleeds (CMBs) and hemorrhagic transformation (HT) after thrombolytic therapy in acute ischemic stroke. Methods A total of 80 acute ischemic stroke patients were consecutively enrolled. According to the SWI with and without CMBs, the patients were divided into CMBs positive group and CMBs negative group. CMBs positive patients were grouped and classified according to the lesion location and number. According to the experimental study of European Cooperative Acute Study (ECASS II), the modified classification of hemorrhagic transformation after thrombolysis was divided into HT negative group, HT-1 type and HT-2 type. Chi-square test were used to compare the statistical difference of the modified classification of HT in CMBs positive and negative groups, in different sites and different numbers of CMBs positive patients, respectively, which had significant difference (P<0.05). Results CMBs accounted for 31.3% in patients with ischemic stroke, and there was significant difference in age between CMBs positive group and CMBs negative group (P<0.05). The incidence, location and number of CMBs showed no significant difference between HT negative group, HT-1 type, and HT-2 type (P>0.05). However, the incidence of type HT-2 was higher in patients with CMBspositive than that in negative patients. Conclusion There was no correlation between the incidence, location and number of CMBs in the brain and post-thrombolysis intracerebral hemorrhage, and CMBs in the brain was not an absolute contraindication of thrombolytic therapy in acute ischemic stroke, although it can increase the risk of HT after thrombolysis.关键词
急性缺血性卒中/脑微出血/出血转化Key words
Acute ischemic stroke/Cerebral microbleeds/Hemorrhagic transformation引用本文复制引用
薛静,王昊,高培毅,祁宇,郝丽娜..脑微出血与急性缺血性卒中溶栓后出血转化的相关性研究[J].中国卒中杂志,2017,12(6):477-483,7.基金项目
"十二五"国家科技支撑计划项目(2011BAI08B09)北京市卫生系统高层次卫生技术人才培养计划(2013-3-049) （2011BAI08B09）
