中国卒中杂志2017，Vol.12Issue(6)：559-565,7.DOI:10.3969/j.issn.1673-5765.2017.06.018
COL4A1/A2基因变异与出血性脑血管病及梗死后出血转化研究进展
Research Progress of COL4A1/A2 Mutations in Hemorrhagic Cerebral Vascular Disease and Hemorrhagic Transformation
摘要
Abstract
Collagen Ⅳ, as a major constituent of all kinds of basement membrane, the defection of which, is associated with the collapse of the blood-brain-barrier (BBB), and also one of the markers to detect the collapse of the BBB in model animals of hemorrhagic cerebral vascular disease. With the help of fast-developing sequencing and analyzing techniques and strategies, such as Genome-wide association study, scientists have revealed the relationship between COL4A1/A2 variants and mendelian diseases, as well as sporadic hemorrhagic cerebral vascular disease. The researches about COLA1/A2 variants and intracerebral hemorrhage, subarachnoid hemorrhage, hemorrhagic transformation are helpful to discover the underlying pathogenesis, screen for high-risk population, early intervening and find new treatment for hemorrhagic cerebral vascular disease.关键词
出血性脑血管病/COL4A1/A2基因/散发性脑血管病/脑出血/蛛网膜下腔出血Key words
Hemorrhagic cerebral vascular disease/COL4A1/A2/Sporadic cerebral vascular disease/Intra-cerebral hemorrhage/Subarachnoid hemorrhage引用本文复制引用
索阅,李伟,王拥军..COL4A1/A2基因变异与出血性脑血管病及梗死后出血转化研究进展[J].中国卒中杂志,2017,12(6):559-565,7.基金项目
重大疾病的防控策略、诊疗规范及效果评价研究(2015BAI12B00) （2015BAI12B00）
