安徽中医药大学学报2017，Vol.36Issue(3)：21-24,4.DOI:10.3969/j.issn.2095-7246.2017.03.007
活血化瘀方联合氯沙坦钾片治疗慢性肾小球肾炎临床观察
Clinical Effect of Huoxue Huayu Prescription Combined with Losartan Potassium Tablets in Treatment of Chronic Glomerulonephritis
摘要
Abstract
Objective To investigate the clinical effect of Huoxue Huayu Prescription combined with conventional Western medicine intervention in the treatment of chronic glomerulonephritis, and to provide a basis for integrated traditional Chinese and Western medicine therapy for chronic glomerulonephritis in clinical practice.Methods A total of 187 patients with chronic glomerulonephritis who met the inclusion criteria were divided into control group and observation group using a random number table.The patients in the control group were given oral losartan potassium tablets, and those in the observation group were given the traditional Chinese medicine Huoxue Huayu Prescription in addition to losartan potassium tablets.Interleukin-1(IL-1), tumor necrosis factor-α(TNF-α), interleukin-13(IL-13), serum creatinine(SCr), blood urea nitrogen(BUN), 24-hour urinary protein quantitation(24hUPro), and hypersensitive C-reactive protein (hsCRP) were measured before and after treatment, and the clinical outcome was compared between the two groups.Results Both groups had significant changes in IL-1, TNF-α, IL-13, SCr, BUN, 24hUPro, and hsCRP after treatment (P<0.05), and there were significant differences between the two groups in IL-1, TNF-α, IL-13, SCr, BUN, 24hUPro, and hsCRP before and after treatment (P<0.05).There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05).Conclusion Integrated traditional Chinese and Western medicine therapy has a marked clinical effect in the treatment of chronic glomerulonephritis.关键词
慢性肾小球肾炎/活血化瘀/氯沙坦钾片/凝血功能Key words
Chronic glomerulonephritis/Huoxue Huayu Prescription/Losartan potassium tablet/Coagulation function分类
医药卫生引用本文复制引用
张永刚,李瑜琳,杨国利,王世兰,张竟,曹灵..活血化瘀方联合氯沙坦钾片治疗慢性肾小球肾炎临床观察[J].安徽中医药大学学报,2017,36(3):21-24,4.基金项目
国家自然科学基金项目(81170667) （81170667）
