安徽中医药大学学报2017，Vol.36Issue(3)：33-36,4.DOI:10.3969/j.issn.2095-7246.2017.03.010
中西药序贯疗法治疗幽门螺杆菌阳性慢性荨麻疹临床研究
Clinical Effect of Sequential Therapy with Chinese and Western Medicines in Treatment of Helicobacter pylori-positive Chronic Urticaria
摘要
Abstract
Objective To investigate the clinical effect of sequential therapy with Chinese and Western medicines in the treatment of Helicobacter pylori-positive chronic urticaria and related mechanisms.Methods A total of 61 patients with Helicobacter pylori-positive chronic urticaria who met the diagnostic criteria were randomly divided into three groups.The 20 patients in the Western medicine group were given oral cetirizine, the 20 patients in the combination group were given four anti-Helicobacter pylori drugs for 2 weeks in addition to the treatment for the Western medicine group, and the 21 patients in the sequential group were given four anti-Helicobacter pylori drugs for 2 weeks in addition to the treatment for the Western medicine group, followed by oral traditional Chinese medicine.The course of treatment was 8 weeks for all groups.The clinical outcome, symptom score, changes in the levels of interleukin-4 (IL-4) and interferon-γ (IFN-γ) after treatment, and Helicobacter pylori clearance rate were observed in all the three groups.Results There was a significant difference in clinical outcome between the three groups (P<0.05), and the sequential group had a significantly better clinical outcome than the Western medicine group and the combination group.After treatment, all the groups had a significant reduction in IL-4 level (P<0.05) and a significant increase in IFN-γ level (P<0.05).The sequential group had a significantly greater decrease in the total symptom score than the Western medicine group and the combination group(P<0.05).There was a significant difference in the Helicobacter pylori clearance rate between the three groups(P<0.05), and the sequential group had the highest Helicobacter pylori clearance rate.Conclusion Sequential therapy with antihistamine combined with four anti-Helicobacter pylori drugs followed by traditional Chinese medicine has a significant clinical effect in the treatment of chronic urticaria with Helicobacter pylori infection.关键词
慢性荨麻疹/幽门螺杆菌/中西药序贯疗法/白细胞介素-4/干扰素-γKey words
Helicobacter pylori/Chronic urticaria/Sequential therapy with Chinese and Western medicines/Interleukin-4/Interferon-γ分类
医药卫生引用本文复制引用
曹宇,李子依,张虹亚,刘涛峰,王建锋..中西药序贯疗法治疗幽门螺杆菌阳性慢性荨麻疹临床研究[J].安徽中医药大学学报,2017,36(3):33-36,4.基金项目
安徽省卫生厅中医药科研计划项目(2014ZY07) （2014ZY07）
