北京生物医学工程2017，Vol.36Issue(3)：268-272,309,6.DOI:10.3969/j.issn.1002-3208.2017.03.08
不同类型突触输入对电突触连接神经元同步化放电的调控
Modulation of neuronal synchronizations between electrically coupled neurons by different synaptic inputs
摘要
Abstract
Objective Synchronous firings exhibit important roles in neural information transmission and encoding,and how to efficiently modulate neuronal synchronizations is always one of the hot spots in brain science research.By means of computer simulations,this paper aims to investigate how synaptic types and relative strengths modulate the synchronization between electrically coupled neurons.Methods Based on the Izhikevich neuron model,a three-neuron network was constructed.By setting one neuron as a modulator,synchronous activities between the other two neurons were numerically analyzed.Results For electrical coupling and excitatory chemical coupling,synchronization strength between the two neurons could be enhanced if the two neurons received synaptic inputs with similar weights.However if the two neurons received synaptic inputs with rather different weights,the synchronization strength could be significantly weakened.For inhibitory chemical coupling,the same conclusion could be drawn when firing frequency of the modulator was low;while higher frequency of the modulator can almost completely suppress the synchronization irrespective of the relative synaptic weights.Conclusions Synchronization strength between electrically coupled neurons can be effectively modulated by the external synaptic inputs,this result promote the exploration about initiation and modulation of synchronization in nervous system.关键词
神经元/同步性/调控/电突触/化学突触Key words
neuron/synchronization/modulation/electrical coupling/chemical coupling分类
医药卫生引用本文复制引用
汪雷..不同类型突触输入对电突触连接神经元同步化放电的调控[J].北京生物医学工程,2017,36(3):268-272,309,6.基金项目
北京市科学技术委员会项目(Z151100000915070)资助 （Z151100000915070）
