摘要
Abstract
Objective To investigate the changes of inflammatory factors in patients with rectal cancer after laparotomy and laparoscopic surgery.Methods 94 patients with rectal cancer treated in our hospital from January 2015 to October 2016 were recruited and randomly divided into the laparotomy group and the laparoscopic group using methods of drawing lots,with 47 cases in each group.Venous blood samples were taken before surgery,1 hour,1 day and 1 week after surgery,in order to measure the expressions of C-reactive protein (CRP),Interleukin-10 (IL-10),tumor necrosis factor α (TNF-α) by ELISA and white blood cell (WBC).The differences of indices related to surgery were compared.Results Serum CRP,IL-10,TNF-α and WBC increased initially in both groups after surgery (P ＜ 0.05),then decreased.1 day after surgery,CRP and WBC in the laparoscopic group were significantly lower than in the laparotomy group (P ＜ 0.05).1 hour and 1 day after surgery,IL-10 and TNF-α in the laparoscopic group were significantly lower than in the laparotomy group (P ＜ 0.05).Intraoperative blood loss,hospitalization time,anal exsufflation time and postoperative feeding time in the laparoscopic group were significantly less or shorter than in the laparotomy group (P ＜ 0.05),The operation time in the laparoscopic group was slightly longer than in the laparotomy group,but the difference was not statistically significant (P ＞ 0.05).Conclusion Laparoscopic surgery for patients with rectal cancer had shorter operation time,minimal trauma,fewer intraoperative blood loss,and good safety.It results in less inflammatory response,less damage to the body,and faster rehabilitation.关键词
直肠癌/腹腔镜根治术/炎性因子Key words
rectal cancer/laparoscopic radical surgery/inflammatory factor分类
医药卫生
