动物营养学报2017，Vol.29Issue(6)：1961-1968,8.DOI:10.3969/j.issn.1006-267x.2017.06.017
饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响
Effects of Pantothenic Acid Supplementation on Lipid Metabolism in Liver of Growing Rex Rabbits
摘要
Abstract
This experiment was conducted to investigate the effects of pantothenic acid supplementation on lipid metabolism in liver of growing Rex rabbits.A total of 160 weaned Rex rabbits with the similar body weight of were randomly divided into 4 groups with 40 replicates per group and 1 rabbit per replicate.Rabbits in the control group were fed a basal diet, and the others in the experimental groups were fed the basal diet supplemented with 10, 20 and 40 mg/kg pantothenic acid, respectively.The pre-test period lasted for 7 days, and the experimental period lasted for 53 days.The results showed that dietary supplemented with 40 mg/kg pantothenic acid significantly increased the scapular fat deposition rate, perigastric fat deposition rate and perirenal fat deposition rate of growing Rex rabbits (P<0.05), and dietary supplemented with 10 to 20 mg/kg pantothenic acid significantly decreased the liver fat droplet content of growing Rex rabbits compared with control group (P<0.05).Dietary pantothenic acid supplemental level had no significant effects on plasma total cholesterol and albumin contents of growing Rex rabbits (P>0.05).With the pantothenic acid supplemental level increasing, the plasma triglyceride content of growing Rex rabbits tended to reduce first and then became stable, and it in 20 and 40 mg/kg supplemental groups was significantly lower than that in control group (P<0.05).Compared with control group, dietary supplemented with 20 to 40 mg/kg pantothenic acid significantly increased the plasma very low density lipoprotein content of growing Rex rabbits (P<0.05).Compared with control group, dietary supplemented with 40 mg/kg pantothenic acid significantly increased the expression levels of hormone-sensitive lipase (HSL) gene in liver and fatty acid transport protein (FATP) gene in skeletal muscle (P<0.05), dietary supplemented with 20 to 40 mg/kg pantothenic acid significantly increased the expression level of carnitine palmityl transferase-1 (CPT1) gene in liver (P<0.05), and dietary supplemented with 10 to 40 mg/kg pantothenic acid significantly increased the expression levels of fatty acid synthase (FAS) gene and CPT1 gene in skeletal muscle (P<0.05).In conclusion, pantothenic acid supplementation affects the lipid metabolism in liver of Rex rabbits.Pantothenic acid with the supplemental level of 40 mg/kg can decrease the lipid deposition in liver and the fat deposition rate of body, and increase the uptake and utilization of fatty acids for skeletal muscle.关键词
獭兔/泛酸/肝脏/脂肪代谢Key words
Rex rabbits/pantothenic acid/liver/lipid metabolism分类
农业科技引用本文复制引用
刘磊,赵楠,张斌,李福昌..饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响[J].动物营养学报,2017,29(6):1961-1968,8.基金项目
中国博士后科学基金项目(2015M58061) （2015M58061）
山东农业大学青年科技创新基金项目(2015-2016) （2015-2016）
山东农业大学博士后科学基金项目(2015-2017) （2015-2017）
现代农业产业技术体系建设专项(CARS-44-B-1) （CARS-44-B-1）
