南方医科大学学报2017，Vol.37Issue(6)：721-729,9.DOI:10.3969/j.issn.1673-4254.2017.06.02
法络氏四联症胎儿大脑沟回发育的产前超声诊断
A prenatal ultrasound study of cerebral sulci and gyrus development in fetuses with tetralogy of Fallot
摘要
Abstract
Objective To evaluate the development of the cerebral sulci and gyrus and cerebral blood flow in fetuses with tetralogy of Fallot (ToF) in the second and third trimesters using ultrasound imaging. Methods Forty fetuses (23-33+6 weeks) with ToF diagnosed using ultrasound imaging between December, 2015 and September, 2016 were analyzed in this study. The development of the cerebral sulci and gyrus was evaluated by measuring the parietal-occipital fissure (POF) depth, POF angle, sylvian fissure (SF) depth, SF width, uncovered insular width, calcarine fissure (CF) depth, hemisphere depth on the views of POF, SF and CF, uncovered insular ratio, biparietal diameter (BPD), and head circumference (HC). Cerebral hemodynamics were assessed by measuring the umbilical artery resistance index, umbilical artery pulsation index, middle cerebral artery pulsation index (MCA-PI), middle cerebral artery resistance index, the cerebral-to-placental resistance ratio, and the cerebroplacental ratio. Results In ToF fetuses, the POF depth, SF depth, CF depth, BPD, HC and hemisphere depth on the views of parietal-occipital sulcus and calcarine sulcus were significantly smaller than those in the control group (P<0.05). The middle cerebral artery resistance index, middle cerebral artery pulsation index, the cerebral-to-placental resistance ratio and the cerebroplacental ratio were also significantly lower in ToF fetuses than in the control group (P<0.05). Conclusion The cerebral sulci and gyrus in ToF fetuses in second and third trimesters show underdevelopment compared with those in normal fetuses, and the changes in hemodynamics caused by abnormal cardiac structure might be one of the reasons for cerebral sulci and gyrus underdevelopment in fetuses with ToF.关键词
法络氏四联症/大脑沟回/产前超声/胎儿Key words
tetralogy of Fallot/cerebral sulci and gyrus/prenatal ultrasound/fetus引用本文复制引用
何嘉敏,李胜利,陈曦,文华轩,袁鹰,罗丹丹..法络氏四联症胎儿大脑沟回发育的产前超声诊断[J].南方医科大学学报,2017,37(6):721-729,9.基金项目
国家自然科学基金(81571758) （81571758）
深圳市科技计划项目(JSGG20160428154812749) （JSGG20160428154812749）
深圳市卫生计生系统科研项目(201506059) Supported by National Natural Science Foundation of China (81571758). （201506059）
