南方医科大学学报2017，Vol.37Issue(6)：744-749,6.DOI:10.3969/j.issn.1673-4254.2017.06.05
cAMP依赖型蛋白激酶抑制剂β在结直肠癌中的表达及其临床意义
Expression of cAMP-dependent protein kinase inhibitor beta in colorectal carcinoma and its clinical significance
摘要
Abstract
Objective To investigate the expression of cAMP-dependent protein kinase inhibitor beta (PKIB) in colorectal carcinoma (CRC) and its association with the clinicopathological factors of the patients. Methods The expression of PKIB mRNA was detected with quantitative real-time PCR in 34 CRC tissues and paired adjacent tissues. Immunohistochemistry was used to detect the expression of PKIB protein in 72 CRC tissue specimens, and the relationship between PKIB protein expression and the clinicopathological features of the patients was analyzed. Results The expression of PKIB mRNA was significantly higher in CRC tissues than in the paired asjacent tissues (P<0.0001). The expression of PKIB protein in CRC patients was closely related with tumor infiltration (T stage) (P=0.038) but not with age, gender, tumor size, location, lymph node metastasis (N stage) or distant metastasis (M stage) (P>0.05). The survival time of patients with high PKIB expressions was significantly shorter than that of patients with low PKIB expressions (70.532 ± 6.190 vs 93.500 ± 5.847 months, P=0.023). Conclusion A high expression of PKIB in CRC is positively correlated with tumor infiltration (T stage) and a poor prognosis, suggesting an important role of PKIB in the development of CRC and its value as an indicator for prognostic evaluation of CRC patients.关键词
结直肠癌/cAMP依赖型蛋白激酶抑制剂β/免疫组织化学/预后/分期Key words
colorectal carcinoma/cAMP-dependent protein kinase inhibitor beta/immunohistochemistry/prognosis/stage引用本文复制引用
王好为,段志娇,胡莎莎,王爽..cAMP依赖型蛋白激酶抑制剂β在结直肠癌中的表达及其临床意义[J].南方医科大学学报,2017,37(6):744-749,6.基金项目
国家自然科学基金(81472318,81172242) Supported by National Natural Science Foundation of China (81472318, 81172242). （81472318,81172242）
