南方医科大学学报2017，Vol.37Issue(6)：755-760,6.DOI:10.3969/j.issn.1673-4254.2017.06.07
认知灵活性的神经动力学:事件相关电位时空模式分析
Neural dynamics of cognitive flexibility: spatiotemporal analysis of event-related potentials
摘要
Abstract
Objective To explore the neural dynamics during alternating task switching. Methods In an alternating-runs paradigm, 23 healthy volunteers were asked to categorize Arabic numerals displayed on the screen into either even or odd numbers or judge if the number was greater than 5 according its color cues. The color of the numerals were regularly switched every three trials (switch, nested and pre-switch trials). ANOVA of repeated-measure and paired t-test were used for analysis of the behavioral performance and event-related potential (ERP) data of 19 channels, and statistical parametric mapping of F and t values was used to reveal the spatiotemporal patterns of ERP. Results Significant switch costs (switch versus nested trial) were found in the mean reaction time (123.61 ± 83.84 ms, P<0.05) and the mean accuracy [(1.24 ± 3.30)%, P<0.05]. Statistical parametric mapping of t value of ERP suggested that the switch effects appeared in the right frontal-parietal network and then in the left one. The preparation effects appeared in the right frontal pole followed by the left one, both accompanied by the activation of the posterior regions. Conclusions Cognitive flexibility depends on the dynamic activation of the fronto-parietal network. The frontal poles are involved in the pre-switch preparatory process, the dorsal frontal areas are related with the actual switch process, and the left and right frontal regions play different roles.关键词
认知灵活性/交替切换/事件相关电位/切换代价/准备效应Key words
cognitive flexibility/alternating runs/event-related potentials/switch cost/preparation effect引用本文复制引用
曹园,周曙,王优..认知灵活性的神经动力学:事件相关电位时空模式分析[J].南方医科大学学报,2017,37(6):755-760,6.基金项目
国家自然科学基金(81200962) （81200962）
南方医科大学南方医院院长基金(2014Z009) Supported by National Natural Science Foundation of China (81200962). （2014Z009）
