南方医科大学学报2017，Vol.37Issue(6)：807-811,5.DOI:10.3969/j.issn.1673-4254.2017.06.16
牙周非手术治疗对肥胖大鼠血清炎症指标及代谢水平的影响
Effects of non-surgical periodontal therapy on serum inflammatory markers and metabolic level in obese rats
摘要
Abstract
Objective To investigate the effects of non-surgical periodontal therapy on serum inflammatory factors and metabolism levels in obese rats with experimental periodontitis. Methods Sixteen obese rats with experimental periodontitis were randomly divided into treatment group and control group with non-surgical periodontal therapy and no treatment, respectively. Oral glucose tolerance test was performed before treatment and 2 weeks after the treatment. All the rats were sacrificed 2 weeks after treatment and the orbital vein blood was taken to detect fasting blood glucose, fasting insulin, and serum level of C-reactive protein (CRP). Results Two weeks after periodontal treatment, fasting blood glucose (t=2.445, P=0.034) and beta cell function index (t=-2.543, P=0.027) were significantly lower in the treatment group than in the control group. Compared with those in the control group, CRP level (t=2.388, P=0.028) and the area under the curve in the oral glucose tolerance test (t=12.053, P=0.000) decreased significantly in the treatment group. Conclusion Non-surgical periodontal treatment can reduce serum CRP level and improve glucose metabolism in obese rats.关键词
牙周非手术治疗/肥胖/炎症因子/代谢水平Key words
non-surgical periodontal therapy/obesity/inflammatory markers/metabolism引用本文复制引用
钟素兰,倪佳,柴巧学,陈蕾,章锦才..牙周非手术治疗对肥胖大鼠血清炎症指标及代谢水平的影响[J].南方医科大学学报,2017,37(6):807-811,5.基金项目
国家自然科学基金(81300890) Supported by National Natural Science Foundation of China (81300890). （81300890）
