广东药学院学报2017，Vol.33Issue(3)：294-298,5.DOI:10.16809/j.cnki.2096-3653.2016112501
5,7,3',4',5'-五甲氧基黄酮平衡溶解度及油水分配系数的测定
Determination of equilibrium solubility and apparent oil-water partition coefficient of 5,7,3',4',5'-pentamethoxyflavone
摘要
Abstract
Objective To determine the equilibrium solubility and apparent oil-water partition coefficients of 5,7,3',4',5'-pentamethoxyflavone (PMFA) and total flavonoids from Bauhinia championii in different pH phosphate buffer solutions.Methods A high performance liquid chromatography method was established to determine the concentrations in water and different pH phosphate buffer solution of PMFA and total flavonoids,while the oil-water partition coefficient for the n-octanol-water/buffer solution system was determined by shaking flask method.Results The equilibrium solubility of PMFA and total flavonoids were 0.603 μg/mL and 77.702 μg/mL in water at 37 ℃.The oil-water partition coefficient of PMFA and total flavonoids were 246.24 (lg Papp=2.39) and 257.51 (lg Papp=2.41),respectively.Conclusion PMFA was not soluble in water,and had moderate lipid solubility.The solubility of PMFA increased in total flavonoids.关键词
龙须藤/总黄酮/5,7,3',4',5'-五甲氧基黄酮/平衡溶解度/表观油水分配系数Key words
Bauhinia championii(Benth.)Benth./5,7,3',4',5'-pentamethoxyflavone/equilibrium solubility/oil-water partition coefficient分类
医药卫生引用本文复制引用
周臻,杨俊腾..5,7,3',4',5'-五甲氧基黄酮平衡溶解度及油水分配系数的测定[J].广东药学院学报,2017,33(3):294-298,5.基金项目
广东药科大学"创新强校工程"项目(51309065) （51309065）
