广东药学院学报2017，Vol.33Issue(3)：366-370,5.DOI:10.16809/j.cnki.2096-3653.2017032406
两种炎症性关节炎小鼠模型的比较
Comparison of two kinds of inflammatory arthritis mouse model
摘要
Abstract
Objective To compare the arthritis features between collagen-induced arthritis (CIA) mice and human tumor necrosis factor alpha transgenic (hTNFa-Tg) mice,providing appropriate animal models for pathogenesis analysis and drug screening of inflammatory arthritis diseases.Methods The inflammatory arthritis in mice were induced by collagen emulsion and human tumor necrosis factor-α gene transfection,which was evaluated,through the joint appearance observation,arthritis index score analysis and pathological observation.Results The pathological score of study,compared with the CIA model,hTNFα-Tg model was the most serious in synovial hyperplasia,that there was statistical difference (P<0.05);in the infiltration of inflammatory cells,CIA model mainly neutrophil infiltration and hTNFα-Tg model is mainly lymphocytic infiltration,and there was a statistical difference(P<0.05);inbone erosion,between CIA model and hTNFα-Tg model,there was no statistical difference(P>0.05).Conclusion The clinical symptoms of two arthritis arthritis models are simulated in a certain extent,and there are also differences between the CIA model which can well simulate the clinical characteristics of rheumatoid arthritis and hTNFα-Tg model which belongs to spontaneity,shows synovial proliferation and is consistent with clinical features advanced RA.关键词
关节炎/小鼠模型/胶原诱导/人肿瘤坏死因子α/炎症Key words
arthritis/mouse model/collagen-induced/human tumor necrosis factor α/inflammation分类
医药卫生引用本文复制引用
叶秋莹,张钰,王晖,李舸,李锦灵,刘书华,李韵峰,何丽芳,吴玉娥,贾欢欢,黄韧..两种炎症性关节炎小鼠模型的比较[J].广东药学院学报,2017,33(3):366-370,5.基金项目
广东省科技计划项目(2013B060300025,2015A030303006,2014A030304029,2016A030303022) （2013B060300025,2015A030303006,2014A030304029,2016A030303022）
