广西医学2017，Vol.39Issue(5)：622-624,639,4.DOI:10.11675/j.issn.0253-4304.2017.05.12
2型糖尿病患者糖脂代谢、胰岛素降解酶活性情况及其与胰岛素抵抗的关系
Relationship of glycolipid metabolism and activity of insulin degrading enzyme with insulin resistance in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the relationship of glycolipid metabolism and insulin-degrading enzyme(IDE) with insulin resistance(IR) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 150 patients with T2DM were selected as diabetes group and 150 healthy individuals as control group.Questionnaire survey,physical examination,and detection of glycolipid metabolism index and IDE activity were conducted.Meanwhile,the homeostasis model of assessment for insulin resistance index(HOMA-IR) was calculated.The glycolipid metabolism index and IDE activity were compared between the two groups,and the correlation of glycolipid metabolism index and IDE activity with HOMA-IR was analyzed.Results Body mass index(BMI),levels of DBP,TG,TC,LDL-C,FBG,2h postprandial plasma glucose (2hPG) and fasting insulin(FINS),HOMA-IR,and IDE activity were higher while the level of HDL-C was lower in the diabetes groups compared to the control group(P<0.05).Correlation analysis showed that HOMA-IR positively correlated with BMI,levels of TG,TC,LDL-C,FBG and 2hPG,FINS,and IDE activity,but negatively correlated with the level of HDL-C(all P<0.05).Multiple linear regression analysis indicated that IDE activity,levels of TG and LDL-C were independent risk factors for HOMA-IR elevation(P<0.05).Conclusion T2DM patients have obvious disorder of glucolipid metabolism as well as increase in the IDE activity.Elevation of IDE activity is one of the risk factors for the incidence of IR in patients with T2DM.关键词
2型糖尿病/胰岛素降解酶/胰岛素抵抗/糖脂代谢Key words
Type 2 diabetes mellitus/Insulin-degrading enzyme/Insulin resistance/Glycolipid metabolism分类
医药卫生引用本文复制引用
汪琳姣,韩晓骏,钱晶,王德琴,江丽华,袁晓岚..2型糖尿病患者糖脂代谢、胰岛素降解酶活性情况及其与胰岛素抵抗的关系[J].广西医学,2017,39(5):622-624,639,4.基金项目
江苏省南通市卫生局青年科研基金项目(WQZ2015012) （WQZ2015012）
