海南医学院学报2017，Vol.23Issue(9)：1183-1186,1190,5.DOI:10.13210/j.cnki.jhmu.20170406.058
曲美他嗪联合比索洛尔对慢性心力衰竭患者心功能、心室重构及神经内分泌因子的影响
Effect of trimetazidine combined with bisoprolol on the cardiac function, ventricular remodeling and neuroendocrine factors in patients with chronic heart failure
摘要
Abstract
Objective: To study the effect of trimetazidine combined with bisoprolol on the cardiac function, ventricular remodeling and neuroendocrine factors in patients with chronic heart failure.Methods: 52 patients with chronic heart failure who were treated in our hospital between January 2012 and November 2015 were collected and divided into the control group (n=26) who received bisoprolol therapy and the observation group (n=26) who received trimetazidine combined with bisoprolol therapy according to the double-blind randomized control method, and both groups were treated for 3 months.Before treatment and after 3 months of treatment, cardiac color Doppler diasonograph was used to determine the levels of cardiac function parameters and ventricular remodeling parameters, and RIA method was used to determine the levels if peripheral blood neuroendocrine factors.Results: Before treatment, the differences in cardiac function, ventricular remodeling and neuroendocrine factor levels were not statistically significant between two groups of patients (P>0.05).After 3 months of treatment, cardiac function parameters LVEDd and LVESD levels of observation group were lower than those of control group while LVEF level was higher than that of control group, and ventricular remodeling parameters LVPWT, IVSS, PWD, PWS and LVMI levels were lower than those of control group (P<0.05);peripheral blood neuroendocrine factors NE, ALD, AngⅡ, ANP and ET contents of observation group were lower than those of control group (P<0.05).Conclusion: Trimetazidine combined with bisoprolol can optimize the cardiac function, suppress the ventricular remodeling process and regulate the neuroendocrine factor secretion in patients with chronic heart failure, and it contributes to the patients' overall optimization.关键词
慢性心力衰竭/曲美他嗪/比索洛尔/心功能/心室重构/神经内分泌因子Key words
Chronic heart failure/Ttrimetazidine/Bisoprolol/Cardiac function/Ventricular remodeling/Neuroendocrine factor分类
医药卫生引用本文复制引用
赵志华..曲美他嗪联合比索洛尔对慢性心力衰竭患者心功能、心室重构及神经内分泌因子的影响[J].海南医学院学报,2017,23(9):1183-1186,1190,5.基金项目
陕西省卫生厅卫生科研基金项目(2010H24) （2010H24）
This Work is Financially Supported by Special Foundation for Clinical Studies from Committee of Medical Journal of Chinese Universities (11221022) （11221022）
